Evaluation of the aldosterone-blocking agent eplerenone in hypertension and heart failure

Jacob George, Allan D. Struthers

    Research output: Contribution to journalReview articlepeer-review

    12 Citations (Scopus)

    Abstract

    Aldosterone blockade is now seen as a crucial therapeutic strategy in the management of cardiovascular disease progression. There is increasing evidence that blocking the rennin-angiotensin-aldosterone system results in a reduction in overall cardiovascular risk. For 40 years, the only agent in this class was spironolactone. Despite its efficacy, the sexual side effects of spironolactone have resulted in poor compliance at best and discontinuation of therapy at worst. A newer agent, eplerenone, has been recently licensed for the treatment of heart failure and in the US also for hypertension. This article reviews the pathophysiology of aldosterone and critically reviews the present evidence for the efficacy and potential role for the new selective aldosterone-receptor antagonist, eplerenone.

    Original languageEnglish
    Pages (from-to)3053-3059
    Number of pages7
    JournalExpert Opinion on Pharmacotherapy
    Volume8
    Issue number17
    DOIs
    Publication statusPublished - Dec 2007

    Keywords

    • aldosterone
    • eplerenone
    • heart failure
    • hypertension
    • MINERALOCORTICOID RECEPTOR ANTAGONISTS
    • RANDOMIZED ALDACTONE EVALUATION
    • LEFT-VENTRICULAR DYSFUNCTION
    • CONVERTING ENZYME-INHIBITOR
    • TO-MODERATE HYPERTENSION
    • MYOCARDIAL-INFARCTION
    • ANTI-ALDOSTERONE
    • ACE-INHIBITION
    • II CONVERSION
    • SPIRONOLACTONE

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