Evaluation of the IRF-2 gene as a candidate for PSORS3

John Foerster; Ilja Nolte; Susann Schweiger; Claudia Ehlert; Marcel Bruinenberg; Katja Spaar; Gerrit van der Steege; Marcel Mulder; Vera Kalscheuer; Bettina Moser; Zofia Kijas; Petra Seeman; Markward Stander; Wolfram Sterry; Gerard te Meerman

doi:10.1046/j.0022-202X.2003.22104.x

Evaluation of the IRF-2 gene as a candidate for PSORS3

John Foerster, Ilja Nolte, Susann Schweiger, Claudia Ehlert, Marcel Bruinenberg, Katja Spaar, Gerrit van der Steege, Marcel Mulder, Vera Kalscheuer, Bettina Moser, Zofia Kijas, Petra Seeman, Markward Stander, Wolfram Sterry, Gerard te Meerman

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Type 1 interferon can trigger flares of psoriasis. Hypersensitivity to type 1 interferon signaling causes a psoriasis-like skin disease in mice deficient for the transcription factor interferon regulatory factor 2 (IRF2). The human IRF2 gene is located at a previously identified candidate psoriasis susceptibility locus on chromosome 4q (PSORS3 at D4S1535). Therefore, we tested association of psoriasis with IRF2. We generated a sample consisting of 157 families with a total of 521 individuals. Five novel microsatellite markers were developed and typed, and complemented with three known markers to yield a set of eight markers spaced within 600 kb around the IRF2 gene, three of which are located in the gene. We detected association of IRF2 with type 1 psoriasis at two markers in the IRF2 gene. Haplotype sharing analysis confirmed association of IRF2 with type 1 psoriasis (p=0.0017; pcorr=0.03). The 921G/A SNP in exon 9 was found to obliterate a predicted exon splice enhancer in an allele-specific manner. There was a suggestive increase of homozygosity for the splicing-deficient allele in type 1 psoriasis patients. Our data identify IRF2 as a potential susceptibility gene for psoriasis.

Original language	English
Pages (from-to)	61-64
Number of pages	4
Journal	Journal of Investigative Dermatology
Volume	122
Issue number	1
DOIs	https://doi.org/10.1046/j.0022-202X.2003.22104.x
Publication status	Published - Jan 2004

Keywords

Psoriasis
DNA-binding proteins genetics
Psoriasis genetics
Repressor proteins
Transcription factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1046/j.0022-202X.2003.22104.x

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title = "Evaluation of the IRF-2 gene as a candidate for PSORS3",

abstract = "Type 1 interferon can trigger flares of psoriasis. Hypersensitivity to type 1 interferon signaling causes a psoriasis-like skin disease in mice deficient for the transcription factor interferon regulatory factor 2 (IRF2). The human IRF2 gene is located at a previously identified candidate psoriasis susceptibility locus on chromosome 4q (PSORS3 at D4S1535). Therefore, we tested association of psoriasis with IRF2. We generated a sample consisting of 157 families with a total of 521 individuals. Five novel microsatellite markers were developed and typed, and complemented with three known markers to yield a set of eight markers spaced within 600 kb around the IRF2 gene, three of which are located in the gene. We detected association of IRF2 with type 1 psoriasis at two markers in the IRF2 gene. Haplotype sharing analysis confirmed association of IRF2 with type 1 psoriasis (p=0.0017; pcorr=0.03). The 921G/A SNP in exon 9 was found to obliterate a predicted exon splice enhancer in an allele-specific manner. There was a suggestive increase of homozygosity for the splicing-deficient allele in type 1 psoriasis patients. Our data identify IRF2 as a potential susceptibility gene for psoriasis.",

keywords = "Psoriasis, DNA-binding proteins genetics, Psoriasis genetics, Repressor proteins, Transcription factors",

author = "John Foerster and Ilja Nolte and Susann Schweiger and Claudia Ehlert and Marcel Bruinenberg and Katja Spaar and {van der Steege}, Gerrit and Marcel Mulder and Vera Kalscheuer and Bettina Moser and Zofia Kijas and Petra Seeman and Markward Stander and Wolfram Sterry and {te Meerman}, Gerard",

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AU - Foerster, John

AU - Nolte, Ilja

AU - Schweiger, Susann

AU - Ehlert, Claudia

AU - Bruinenberg, Marcel

AU - Spaar, Katja

AU - van der Steege, Gerrit

AU - Mulder, Marcel

AU - Kalscheuer, Vera

AU - Moser, Bettina

AU - Kijas, Zofia

AU - Seeman, Petra

AU - Stander, Markward

AU - Sterry, Wolfram

AU - te Meerman, Gerard

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AB - Type 1 interferon can trigger flares of psoriasis. Hypersensitivity to type 1 interferon signaling causes a psoriasis-like skin disease in mice deficient for the transcription factor interferon regulatory factor 2 (IRF2). The human IRF2 gene is located at a previously identified candidate psoriasis susceptibility locus on chromosome 4q (PSORS3 at D4S1535). Therefore, we tested association of psoriasis with IRF2. We generated a sample consisting of 157 families with a total of 521 individuals. Five novel microsatellite markers were developed and typed, and complemented with three known markers to yield a set of eight markers spaced within 600 kb around the IRF2 gene, three of which are located in the gene. We detected association of IRF2 with type 1 psoriasis at two markers in the IRF2 gene. Haplotype sharing analysis confirmed association of IRF2 with type 1 psoriasis (p=0.0017; pcorr=0.03). The 921G/A SNP in exon 9 was found to obliterate a predicted exon splice enhancer in an allele-specific manner. There was a suggestive increase of homozygosity for the splicing-deficient allele in type 1 psoriasis patients. Our data identify IRF2 as a potential susceptibility gene for psoriasis.

KW - Psoriasis

KW - DNA-binding proteins genetics

KW - Psoriasis genetics

KW - Repressor proteins

KW - Transcription factors

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Evaluation of the IRF-2 gene as a candidate for PSORS3

Abstract

Keywords

UN SDGs

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