Identification of unilateral aldosterone-producing (Conn's) adenomas has traditionally required lateralization by the invasive and technically difficult procedure of adrenal vein sampling (AVS). (11)C-metomidate, a potent inhibitor of adrenal steroidogenic enzymes, is a positron emission tomography (PET) radiotracer that is selectively accumulated by Conn's adenomas.
Burton, T. J., Mackenzie, I. S., Balan, K., Koo, B., Bird, N., Soloviev, D. V., Azizan, E. A. B., Aigbirhio, F., Gurnell, M., & Brown, M. J. (2012). Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas. Journal of Clinical Endocrinology & Metabolism, 97(1), 100-9. https://doi.org/10.1210/jc.2011-1537