Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas

Timothy J Burton, Isla S Mackenzie, Kottekkattu Balan, Brendan Koo, Nick Bird, Dmitri V Soloviev, Elena A B Azizan, Franklin Aigbirhio, Mark Gurnell, Morris J Brown

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    104 Citations (Scopus)

    Abstract

    Identification of unilateral aldosterone-producing (Conn's) adenomas has traditionally required lateralization by the invasive and technically difficult procedure of adrenal vein sampling (AVS). (11)C-metomidate, a potent inhibitor of adrenal steroidogenic enzymes, is a positron emission tomography (PET) radiotracer that is selectively accumulated by Conn's adenomas.
    Original languageEnglish
    Pages (from-to)100-9
    Number of pages10
    JournalJournal of Clinical Endocrinology & Metabolism
    Volume97
    Issue number1
    DOIs
    Publication statusPublished - 2012

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