Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas

Timothy J Burton; Isla S Mackenzie; Kottekkattu Balan; Brendan Koo; Nick Bird; Dmitri V Soloviev; Elena A B Azizan; Franklin Aigbirhio; Mark Gurnell; Morris J Brown

doi:10.1210/jc.2011-1537

Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas

Timothy J Burton
, Isla S Mackenzie
, Kottekkattu Balan
, Brendan Koo
, Nick Bird
, Dmitri V Soloviev
, Elena A B Azizan
, Franklin Aigbirhio
, Mark Gurnell
, Morris J Brown

Research output: Contribution to journal › Article › peer-review

228 Citations (Scopus)

Abstract

Identification of unilateral aldosterone-producing (Conn's) adenomas has traditionally required lateralization by the invasive and technically difficult procedure of adrenal vein sampling (AVS). (11)C-metomidate, a potent inhibitor of adrenal steroidogenic enzymes, is a positron emission tomography (PET) radiotracer that is selectively accumulated by Conn's adenomas.

Original language	English
Pages (from-to)	100-9
Number of pages	10
Journal	Journal of Clinical Endocrinology & Metabolism
Volume	97
Issue number	1
DOIs	https://doi.org/10.1210/jc.2011-1537
Publication status	Published - 2012

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10.1210/jc.2011-1537

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Burton, T. J., Mackenzie, I. S., Balan, K., Koo, B., Bird, N., Soloviev, D. V., Azizan, E. A. B., Aigbirhio, F., Gurnell, M., & Brown, M. J. (2012). Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas. Journal of Clinical Endocrinology & Metabolism, 97(1), 100-9. https://doi.org/10.1210/jc.2011-1537

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abstract = "Identification of unilateral aldosterone-producing (Conn's) adenomas has traditionally required lateralization by the invasive and technically difficult procedure of adrenal vein sampling (AVS). (11)C-metomidate, a potent inhibitor of adrenal steroidogenic enzymes, is a positron emission tomography (PET) radiotracer that is selectively accumulated by Conn's adenomas.",

author = "Burton, \{Timothy J\} and Mackenzie, \{Isla S\} and Kottekkattu Balan and Brendan Koo and Nick Bird and Soloviev, \{Dmitri V\} and Azizan, \{Elena A B\} and Franklin Aigbirhio and Mark Gurnell and Brown, \{Morris J\}",

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language = "English",

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Burton, TJ, Mackenzie, IS, Balan, K, Koo, B, Bird, N, Soloviev, DV, Azizan, EAB, Aigbirhio, F, Gurnell, M & Brown, MJ 2012, 'Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas', Journal of Clinical Endocrinology & Metabolism, vol. 97, no. 1, pp. 100-9. https://doi.org/10.1210/jc.2011-1537

Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas. / Burton, Timothy J; Mackenzie, Isla S; Balan, Kottekkattu et al.
In: Journal of Clinical Endocrinology & Metabolism, Vol. 97, No. 1, 2012, p. 100-9.

Research output: Contribution to journal › Article › peer-review

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AU - Bird, Nick

AU - Soloviev, Dmitri V

AU - Azizan, Elena A B

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AB - Identification of unilateral aldosterone-producing (Conn's) adenomas has traditionally required lateralization by the invasive and technically difficult procedure of adrenal vein sampling (AVS). (11)C-metomidate, a potent inhibitor of adrenal steroidogenic enzymes, is a positron emission tomography (PET) radiotracer that is selectively accumulated by Conn's adenomas.

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Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas

Abstract

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