Evidence for a proximal and distal nephron action of atrial natriuretic factor in man

J. McMurray, P. H. Seidelin, A. D. Struthers

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    The intrarenal mechanism of action of atrial natriuretic (ANF) remains uncertain. Animal work suggests that part of the natriuretic effect of ANF may be due to inhibition of proximal and distal nephron sodium reabsorption and we now present evidence for similar effects of ANF in man. Six sodium replete normal male volunteers were studied during maximal water diuresis. Lithium clearance was used to assess segmental nephron function. ANF infusion caused a significant increase in fractional lithium clearance (FELi) compared to placebo infusion. A similar change in fractional distal delivery, a conventional marker of proximal tubular outflow, also occurred during ANF infusion independently corroborating the increase in FELi. These findings suggest that ANF inhibits whole-kidney fractional proximal tubular sodium reabsorption in man. Evidence is also presented to show that ANF depresses distal nephron fractional sodium reabsorption as evaluated both by the lithium method and by estimation of solute-free water clearance.

    Original languageEnglish
    Pages (from-to)39-43
    Number of pages5
    JournalNephron
    Volume51
    Issue number1
    DOIs
    Publication statusPublished - 1989

    Fingerprint

    Nephrons
    Atrial Natriuretic Factor
    Sodium
    Lithium
    Natriuretic Agents
    Water
    Diuresis
    Healthy Volunteers
    Placebos
    Kidney

    Cite this

    McMurray, J. ; Seidelin, P. H. ; Struthers, A. D. / Evidence for a proximal and distal nephron action of atrial natriuretic factor in man. In: Nephron. 1989 ; Vol. 51, No. 1. pp. 39-43.
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    Evidence for a proximal and distal nephron action of atrial natriuretic factor in man. / McMurray, J.; Seidelin, P. H.; Struthers, A. D.

    In: Nephron, Vol. 51, No. 1, 1989, p. 39-43.

    Research output: Contribution to journalArticle

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    AU - McMurray, J.

    AU - Seidelin, P. H.

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    AB - The intrarenal mechanism of action of atrial natriuretic (ANF) remains uncertain. Animal work suggests that part of the natriuretic effect of ANF may be due to inhibition of proximal and distal nephron sodium reabsorption and we now present evidence for similar effects of ANF in man. Six sodium replete normal male volunteers were studied during maximal water diuresis. Lithium clearance was used to assess segmental nephron function. ANF infusion caused a significant increase in fractional lithium clearance (FELi) compared to placebo infusion. A similar change in fractional distal delivery, a conventional marker of proximal tubular outflow, also occurred during ANF infusion independently corroborating the increase in FELi. These findings suggest that ANF inhibits whole-kidney fractional proximal tubular sodium reabsorption in man. Evidence is also presented to show that ANF depresses distal nephron fractional sodium reabsorption as evaluated both by the lithium method and by estimation of solute-free water clearance.

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