Evidence for the stress-linked immunocompetence handicap hypothesis in humans

Markus J. Rantala, Fhionna R. Moore (Lead / Corresponding author), Ilona Skrinda, Tatjana Krama, Inese Kivleniece, Sanita Kecko, Indrikis Krams

    Research output: Contribution to journalArticle

    94 Citations (Scopus)

    Abstract

    Secondary sexual traits that develop under the action of testosterone, such as masculine human male facial characteristics, have been proposed to signal the strength of the immune system due to the sex hormone's immunosuppressive action. Recent work has suggested that glucocorticoid stress hormones may also influence expression of such sexual signals due to their effects on immune function. Precise roles, however, remain unclear. Here we show positive relationships between testosterone, facial attractiveness and immune function (antibody response to a hepatitis B vaccine) in human males, and present some preliminary evidence that these relationships are moderated by naturally co-occurring cortisol (a glucocorticoid stress hormone involved in the fight-or-flight response). We conclude that our results provide support for a role of glucocorticoids in hormonally mediated sexual selection.
    Original languageEnglish
    Article number694
    JournalNature Communications
    Volume3
    DOIs
    Publication statusPublished - 21 Feb 2012

    Fingerprint

    glucocorticoids
    disabilities
    Immunocompetence
    hormones
    Glucocorticoids
    Testosterone
    Hormones
    vaccines
    hepatitis
    immune systems
    Hepatitis B Vaccines
    Immune system
    Gonadal Steroid Hormones
    Immunosuppressive Agents
    antibodies
    Antibody Formation
    Hydrocortisone
    Immune System
    flight
    Antibodies

    Cite this

    Rantala, M. J., Moore, F. R., Skrinda, I., Krama, T., Kivleniece, I., Kecko, S., & Krams, I. (2012). Evidence for the stress-linked immunocompetence handicap hypothesis in humans. Nature Communications, 3, [694]. https://doi.org/10.1038/ncomms1696
    Rantala, Markus J. ; Moore, Fhionna R. ; Skrinda, Ilona ; Krama, Tatjana ; Kivleniece, Inese ; Kecko, Sanita ; Krams, Indrikis. / Evidence for the stress-linked immunocompetence handicap hypothesis in humans. In: Nature Communications. 2012 ; Vol. 3.
    @article{eff44f5bc4ec40a496279614705b7fe1,
    title = "Evidence for the stress-linked immunocompetence handicap hypothesis in humans",
    abstract = "Secondary sexual traits that develop under the action of testosterone, such as masculine human male facial characteristics, have been proposed to signal the strength of the immune system due to the sex hormone's immunosuppressive action. Recent work has suggested that glucocorticoid stress hormones may also influence expression of such sexual signals due to their effects on immune function. Precise roles, however, remain unclear. Here we show positive relationships between testosterone, facial attractiveness and immune function (antibody response to a hepatitis B vaccine) in human males, and present some preliminary evidence that these relationships are moderated by naturally co-occurring cortisol (a glucocorticoid stress hormone involved in the fight-or-flight response). We conclude that our results provide support for a role of glucocorticoids in hormonally mediated sexual selection.",
    author = "Rantala, {Markus J.} and Moore, {Fhionna R.} and Ilona Skrinda and Tatjana Krama and Inese Kivleniece and Sanita Kecko and Indrikis Krams",
    year = "2012",
    month = "2",
    day = "21",
    doi = "10.1038/ncomms1696",
    language = "English",
    volume = "3",
    journal = "Nature Communications",
    issn = "2041-1723",
    publisher = "Nature Publishing Group",

    }

    Evidence for the stress-linked immunocompetence handicap hypothesis in humans. / Rantala, Markus J.; Moore, Fhionna R. (Lead / Corresponding author); Skrinda, Ilona; Krama, Tatjana; Kivleniece, Inese; Kecko, Sanita; Krams, Indrikis.

    In: Nature Communications, Vol. 3, 694, 21.02.2012.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Evidence for the stress-linked immunocompetence handicap hypothesis in humans

    AU - Rantala, Markus J.

    AU - Moore, Fhionna R.

    AU - Skrinda, Ilona

    AU - Krama, Tatjana

    AU - Kivleniece, Inese

    AU - Kecko, Sanita

    AU - Krams, Indrikis

    PY - 2012/2/21

    Y1 - 2012/2/21

    N2 - Secondary sexual traits that develop under the action of testosterone, such as masculine human male facial characteristics, have been proposed to signal the strength of the immune system due to the sex hormone's immunosuppressive action. Recent work has suggested that glucocorticoid stress hormones may also influence expression of such sexual signals due to their effects on immune function. Precise roles, however, remain unclear. Here we show positive relationships between testosterone, facial attractiveness and immune function (antibody response to a hepatitis B vaccine) in human males, and present some preliminary evidence that these relationships are moderated by naturally co-occurring cortisol (a glucocorticoid stress hormone involved in the fight-or-flight response). We conclude that our results provide support for a role of glucocorticoids in hormonally mediated sexual selection.

    AB - Secondary sexual traits that develop under the action of testosterone, such as masculine human male facial characteristics, have been proposed to signal the strength of the immune system due to the sex hormone's immunosuppressive action. Recent work has suggested that glucocorticoid stress hormones may also influence expression of such sexual signals due to their effects on immune function. Precise roles, however, remain unclear. Here we show positive relationships between testosterone, facial attractiveness and immune function (antibody response to a hepatitis B vaccine) in human males, and present some preliminary evidence that these relationships are moderated by naturally co-occurring cortisol (a glucocorticoid stress hormone involved in the fight-or-flight response). We conclude that our results provide support for a role of glucocorticoids in hormonally mediated sexual selection.

    UR - http://www.scopus.com/inward/record.url?scp=84857750893&partnerID=8YFLogxK

    U2 - 10.1038/ncomms1696

    DO - 10.1038/ncomms1696

    M3 - Article

    VL - 3

    JO - Nature Communications

    JF - Nature Communications

    SN - 2041-1723

    M1 - 694

    ER -