Evidence in humans for a postsynaptic interaction between noradrenaline and angiotensin II with regard to systolic but not diastolic blood pressure

Allan D. Struthers, Sudha Pai, Peter H. Seidelin, Wendy J. R. Coutie, John J. Morton

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    Abstract

    Much animal evidence exists to suggest that there is an interaction between noradrenaline (NA) and angiotensin II (AII). We have now sought evidence for a postsynaptic AII/NA interaction. Ten normotensive volunteers were infused with dextrose/saline, All/saline, dextrose/NA or AII/NA in a randomized single-blind fashion. The respective increases in systolic blood pressure (SBP) were -4 ± 6, -2 ± 9, 4 ± 6 and 14 ± 16 mmHg at comparative time intervals while the corresponding increases in diastolic blood pressure (DBP) were 2 ± 4, 6 ± 7, 9 ± 6 and 14 ± 8 mmHg. ANOVA confirmed that AII and NA had a synergistic interaction (P < 0.05) in elevating SBP while there was merely an additive effect in elevating DBP. Plasma NA and AII levels were unchanged by the coincidental presence of AII and NA, respectively, which excludes a generalized pharmacokinetic interaction between AII and NA. This study provides evidence for a postsynaptic AII/NA interaction with regard to SBP but not DBP although the precise location of this interaction remains uncertain. Therefore, in considering the pathogenesis of SBP abnormalities, concomitant measurements of both NA and AII may be important.
    Original languageEnglish
    Pages (from-to)671-676
    Number of pages6
    JournalJournal of Hypertension
    Volume5
    Issue number6
    Publication statusPublished - Dec 1987

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    Angiotensin II
    Norepinephrine
    Blood Pressure
    Glucose
    Volunteers
    Analysis of Variance
    Pharmacokinetics

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    title = "Evidence in humans for a postsynaptic interaction between noradrenaline and angiotensin II with regard to systolic but not diastolic blood pressure",
    abstract = "Much animal evidence exists to suggest that there is an interaction between noradrenaline (NA) and angiotensin II (AII). We have now sought evidence for a postsynaptic AII/NA interaction. Ten normotensive volunteers were infused with dextrose/saline, All/saline, dextrose/NA or AII/NA in a randomized single-blind fashion. The respective increases in systolic blood pressure (SBP) were -4 ± 6, -2 ± 9, 4 ± 6 and 14 ± 16 mmHg at comparative time intervals while the corresponding increases in diastolic blood pressure (DBP) were 2 ± 4, 6 ± 7, 9 ± 6 and 14 ± 8 mmHg. ANOVA confirmed that AII and NA had a synergistic interaction (P < 0.05) in elevating SBP while there was merely an additive effect in elevating DBP. Plasma NA and AII levels were unchanged by the coincidental presence of AII and NA, respectively, which excludes a generalized pharmacokinetic interaction between AII and NA. This study provides evidence for a postsynaptic AII/NA interaction with regard to SBP but not DBP although the precise location of this interaction remains uncertain. Therefore, in considering the pathogenesis of SBP abnormalities, concomitant measurements of both NA and AII may be important.",
    author = "Struthers, {Allan D.} and Sudha Pai and Seidelin, {Peter H.} and Coutie, {Wendy J. R.} and Morton, {John J.}",
    year = "1987",
    month = "12",
    language = "English",
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    pages = "671--676",
    journal = "Journal of Hypertension",
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    Evidence in humans for a postsynaptic interaction between noradrenaline and angiotensin II with regard to systolic but not diastolic blood pressure. / Struthers, Allan D.; Pai, Sudha; Seidelin, Peter H.; Coutie, Wendy J. R.; Morton, John J.

    In: Journal of Hypertension, Vol. 5, No. 6, 12.1987, p. 671-676.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Evidence in humans for a postsynaptic interaction between noradrenaline and angiotensin II with regard to systolic but not diastolic blood pressure

    AU - Struthers, Allan D.

    AU - Pai, Sudha

    AU - Seidelin, Peter H.

    AU - Coutie, Wendy J. R.

    AU - Morton, John J.

    PY - 1987/12

    Y1 - 1987/12

    N2 - Much animal evidence exists to suggest that there is an interaction between noradrenaline (NA) and angiotensin II (AII). We have now sought evidence for a postsynaptic AII/NA interaction. Ten normotensive volunteers were infused with dextrose/saline, All/saline, dextrose/NA or AII/NA in a randomized single-blind fashion. The respective increases in systolic blood pressure (SBP) were -4 ± 6, -2 ± 9, 4 ± 6 and 14 ± 16 mmHg at comparative time intervals while the corresponding increases in diastolic blood pressure (DBP) were 2 ± 4, 6 ± 7, 9 ± 6 and 14 ± 8 mmHg. ANOVA confirmed that AII and NA had a synergistic interaction (P < 0.05) in elevating SBP while there was merely an additive effect in elevating DBP. Plasma NA and AII levels were unchanged by the coincidental presence of AII and NA, respectively, which excludes a generalized pharmacokinetic interaction between AII and NA. This study provides evidence for a postsynaptic AII/NA interaction with regard to SBP but not DBP although the precise location of this interaction remains uncertain. Therefore, in considering the pathogenesis of SBP abnormalities, concomitant measurements of both NA and AII may be important.

    AB - Much animal evidence exists to suggest that there is an interaction between noradrenaline (NA) and angiotensin II (AII). We have now sought evidence for a postsynaptic AII/NA interaction. Ten normotensive volunteers were infused with dextrose/saline, All/saline, dextrose/NA or AII/NA in a randomized single-blind fashion. The respective increases in systolic blood pressure (SBP) were -4 ± 6, -2 ± 9, 4 ± 6 and 14 ± 16 mmHg at comparative time intervals while the corresponding increases in diastolic blood pressure (DBP) were 2 ± 4, 6 ± 7, 9 ± 6 and 14 ± 8 mmHg. ANOVA confirmed that AII and NA had a synergistic interaction (P < 0.05) in elevating SBP while there was merely an additive effect in elevating DBP. Plasma NA and AII levels were unchanged by the coincidental presence of AII and NA, respectively, which excludes a generalized pharmacokinetic interaction between AII and NA. This study provides evidence for a postsynaptic AII/NA interaction with regard to SBP but not DBP although the precise location of this interaction remains uncertain. Therefore, in considering the pathogenesis of SBP abnormalities, concomitant measurements of both NA and AII may be important.

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