Evidence of an interaction between nifedipine and nafcillin in humans

C C Lang; S K Jamal; Z Mohamed; M R Mustafa; A M Mustafa; T C Lee

doi:10.1046/j.1365-2125.2003.01789.x

Evidence of an interaction between nifedipine and nafcillin in humans

C C Lang, S K Jamal, Z Mohamed, M R Mustafa, A M Mustafa, T C Lee

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P-450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4.

Original language	English
Pages (from-to)	588-90
Number of pages	3
Journal	British Journal of Clinical Pharmacology
Volume	55
Issue number	6
DOIs	https://doi.org/10.1046/j.1365-2125.2003.01789.x
Publication status	Published - 2003

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10.1046/j.1365-2125.2003.01789.x

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title = "Evidence of an interaction between nifedipine and nafcillin in humans",

abstract = "Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P-450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4.",

author = "Lang, {C C} and Jamal, {S K} and Z Mohamed and Mustafa, {M R} and Mustafa, {A M} and Lee, {T C}",

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T1 - Evidence of an interaction between nifedipine and nafcillin in humans

AU - Lang, C C

AU - Jamal, S K

AU - Mohamed, Z

AU - Mustafa, M R

AU - Mustafa, A M

AU - Lee, T C

PY - 2003

Y1 - 2003

N2 - Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P-450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4.

AB - Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P-450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4.

U2 - 10.1046/j.1365-2125.2003.01789.x

DO - 10.1046/j.1365-2125.2003.01789.x

M3 - Article

C2 - 12814453

SN - 0306-5251

VL - 55

SP - 588

EP - 590

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 6

ER -

Evidence of an interaction between nifedipine and nafcillin in humans

Abstract

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