Evidence of an interaction between nifedipine and nafcillin in humans

TY - JOUR

T1 - Evidence of an interaction between nifedipine and nafcillin in humans

AU - Lang, C C

AU - Jamal, S K

AU - Mohamed, Z

AU - Mustafa, M R

AU - Mustafa, A M

AU - Lee, T C

PY - 2003

Y1 - 2003

N2 - Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P-450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4.

AB - Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P-450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4.

U2 - 10.1046/j.1365-2125.2003.01789.x

DO - 10.1046/j.1365-2125.2003.01789.x

M3 - Article

C2 - 12814453

SN - 0306-5251

VL - 55

SP - 588

EP - 590

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 6

ER -