Evidence of field change in oral cancer

G.R. Ogden, J.G. Cowpe, Michael Green

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    20 Citations (Scopus)


    Evidence of field change in oral cancer was assessed using quantitative cytomorphometric analysis of smears taken from normal buccal mucosa in oral cancer-free patients. The nuclear areas (NA) and cytoplasmic areas (CA) were calculated using a semi-automatic image analysis system. A statistically significant reduction in CA (p = 0.002) but no change in NA was observed for the oral cancer group. This change occurred irrespective of tobacco and alcohol usage. We believe this to be the first evidence for true field change since Slaughter's original hypothesis in 1946.
    Original languageEnglish
    Pages (from-to)390-392
    Number of pages3
    JournalBritish Journal of Oral and Maxillofacial Surgery
    Issue number6
    Publication statusPublished - 1 Jan 1990


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