TY - JOUR
T1 - Evidence of field change in oral cancer
AU - Ogden, G.R.
AU - Cowpe, J.G.
AU - Green, Michael
PY - 1990/1/1
Y1 - 1990/1/1
N2 - Evidence of field change in oral cancer was assessed using quantitative cytomorphometric analysis of smears taken from normal buccal mucosa in oral cancer-free patients. The nuclear areas (NA) and cytoplasmic areas (CA) were calculated using a semi-automatic image analysis system. A statistically significant reduction in CA (p = 0.002) but no change in NA was observed for the oral cancer group. This change occurred irrespective of tobacco and alcohol usage. We believe this to be the first evidence for true field change since Slaughter's original hypothesis in 1946.
AB - Evidence of field change in oral cancer was assessed using quantitative cytomorphometric analysis of smears taken from normal buccal mucosa in oral cancer-free patients. The nuclear areas (NA) and cytoplasmic areas (CA) were calculated using a semi-automatic image analysis system. A statistically significant reduction in CA (p = 0.002) but no change in NA was observed for the oral cancer group. This change occurred irrespective of tobacco and alcohol usage. We believe this to be the first evidence for true field change since Slaughter's original hypothesis in 1946.
UR - http://www.scopus.com/inward/record.url?scp=0025666936&partnerID=8YFLogxK
U2 - 10.1016/0266-4356(90)90036-K
DO - 10.1016/0266-4356(90)90036-K
M3 - Article
AN - SCOPUS:0025666936
SN - 0266-4356
VL - 28
SP - 390
EP - 392
JO - British Journal of Oral and Maxillofacial Surgery
JF - British Journal of Oral and Maxillofacial Surgery
IS - 6
ER -
