Evidence that protein kinase C differentially regulates the human T lymphocyte CD2 and CD3 surface antigens

Doreen A. Cantrell, Winston Verbi, Adelina Davies, Peter Parke, Michael J. Crumpton

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The purpose of the present study was to explore the effects of protein kinase C (PKC) stimulation on two cell surface receptors that regulate T cell growth: the T cell antigen receptor/CD3 complex and the CD2 antigen. The data show that PKC differentially regulates the expression and functions of CD2 and CD3 molecules. Thus, activation of PKC induced a decrease in cell surface levels of CD3 molecules but an increase in the expression of CD2 antigens. Additionally, prolonged stimulation of PKC inhibited subsequent T cell activation via CD3 but promoted activation via CD2 molecules. These results suggest that the CD2 cellular activation pathway would be preferred in T cells which have been exposed to stimulators of PKC. The molecular basis for the regulatory effects of PKC on CD3 and CD2 molecules and its physiological significance are discussed.

Original languageEnglish
Pages (from-to)1391-1396
Number of pages6
JournalEuropean Journal of Immunology
Volume18
Issue number9
DOIs
Publication statusPublished - Sep 1988

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