TY - JOUR
T1 - Evidence that protein kinase C differentially regulates the human T lymphocyte CD2 and CD3 surface antigens
AU - Cantrell, Doreen A.
AU - Verbi, Winston
AU - Davies, Adelina
AU - Parke, Peter
AU - Crumpton, Michael J.
PY - 1988/9
Y1 - 1988/9
N2 - The purpose of the present study was to explore the effects of protein kinase C (PKC) stimulation on two cell surface receptors that regulate T cell growth: the T cell antigen receptor/CD3 complex and the CD2 antigen. The data show that PKC differentially regulates the expression and functions of CD2 and CD3 molecules. Thus, activation of PKC induced a decrease in cell surface levels of CD3 molecules but an increase in the expression of CD2 antigens. Additionally, prolonged stimulation of PKC inhibited subsequent T cell activation via CD3 but promoted activation via CD2 molecules. These results suggest that the CD2 cellular activation pathway would be preferred in T cells which have been exposed to stimulators of PKC. The molecular basis for the regulatory effects of PKC on CD3 and CD2 molecules and its physiological significance are discussed.
AB - The purpose of the present study was to explore the effects of protein kinase C (PKC) stimulation on two cell surface receptors that regulate T cell growth: the T cell antigen receptor/CD3 complex and the CD2 antigen. The data show that PKC differentially regulates the expression and functions of CD2 and CD3 molecules. Thus, activation of PKC induced a decrease in cell surface levels of CD3 molecules but an increase in the expression of CD2 antigens. Additionally, prolonged stimulation of PKC inhibited subsequent T cell activation via CD3 but promoted activation via CD2 molecules. These results suggest that the CD2 cellular activation pathway would be preferred in T cells which have been exposed to stimulators of PKC. The molecular basis for the regulatory effects of PKC on CD3 and CD2 molecules and its physiological significance are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0023787580&partnerID=8YFLogxK
U2 - 10.1002/eji.1830180914
DO - 10.1002/eji.1830180914
M3 - Article
C2 - 2901966
AN - SCOPUS:0023787580
SN - 0014-2980
VL - 18
SP - 1391
EP - 1396
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 9
ER -