Evolution and diversification of the nuclear pore complex

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Abstract

The nuclear pore complex (NPC) is responsible for transport between the cytoplasm and nucleoplasm and one of the more intricate structures of eukaryotic cells. Typically composed of over 300 polypeptides, the NPC shares evolutionary origins with endo-membrane and intraflagellar transport system complexes. The modern NPC was fully established by the time of the last eukaryotic common ancestor and, hence, prior to eukaryote diversification. Despite the complexity, the NPC structure is surprisingly flexible with considerable variation between lineages. Here, we review diversification of the NPC in major taxa in view of recent advances in genomic and structural characterisation of plant, protist and nucleomorph NPCs and discuss the implications for NPC evolution. Furthermore, we highlight these changes in the context of mRNA export and consider how this process may have influenced NPC diversity. We reveal the NPC as a platform for continual evolution and adaptation.

Original languageEnglish
Pages (from-to)1601-1619
Number of pages19
JournalBiochemical Society Transactions
Volume49
Issue number4
Early online date20 Jul 2021
DOIs
Publication statusPublished - 27 Aug 2021

Keywords

  • Nuclear pore complex
  • mRNA processing
  • trypanosome
  • gene expression
  • evolution
  • eukaryogenesis

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