Evolution, function and roles in drug sensitivity of trypanosome aquaglyceroporins

Juan F. Quintana, Mark C. Field (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Aquaglyceroporins (AQPs) are membrane proteins that function in osmoregulation and the uptake of low molecular weight solutes, in particular glycerol and urea. The AQP family is highly conserved, with two major subfamilies having arisen very early in prokaryote evolution and retained by eukaryotes. A complex evolutionary history indicates multiple lineage-specific expansions, losses and not uncommonly a complete loss. Consequently, the AQP family are highly evolvable and have been associated with significant events in life on Earth. In the African trypanosomes a role for the AQP2 paralog, in sensitivity to two chemotherapeutic agents, pentamidine and melarsoprol, are well established, albeit with the mechanisms for cell entry and resistance unclear until very recently. Here we discuss AQP evolution, structure and mechanisms by which AQPs impact drug sensitivity, suggesting that AQP2 stability is highly sensitive to mutation while serving as the major uptake pathway for pentamidine.
Original languageEnglish
JournalParasitology
DOIs
Publication statusE-pub ahead of print - 19 Feb 2021

Keywords

  • Aquaglyceroporin
  • membrane trafficking
  • pentamidine
  • drug resistance
  • Trypanosoma brucei
  • sleeping sickness

Fingerprint

Dive into the research topics of 'Evolution, function and roles in drug sensitivity of trypanosome aquaglyceroporins'. Together they form a unique fingerprint.

Cite this