Abstract
The kinetoplastida and their close relatives are unicellular organisms prevalent within the eukaryotic biosphere and important for significant impacts on global health, economy and ecosystems. They are, under most models, an early branching lineage. Individual species adapted to highly diverse environments by adopting complex life styles; parasitic species can infect a wide range of eukaryotic hosts, while many relatives are free-living and some autotrophic from acquiring a plastid for photosynthesis. Adaptation is especially evident in the evolution of kinetoplastid cell surface architecture and is supported by endomembrane trafficking and serves as a platform for interaction with environment. Here we summarize and discuss recent genomic and experimental studies of the protein trafficking system in kinetoplastids, with focus on the composition and function of the surface as well as mechanisms for constructing, maintaining and regulating the cell surface proteome. We hope this provides a broad view of how protein trafficking contributes to the intricate and dynamic host-parasite interfaces that are critical for successful environmental adaptation of this highly important lineage. This article is protected by copyright. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 803-812 |
| Number of pages | 10 |
| Journal | Traffic |
| Volume | 19 |
| Issue number | 11 |
| Early online date | 4 Jul 2018 |
| DOIs | |
| Publication status | Published - Nov 2018 |
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Keywords
- Endomembrane system
- evolution
- trypanosomes
- kinetoplastida
- parasitism
- plasma membrane
- endocytosis
- pathogenesis
- drug mode of action
- endomembrane system
Cite this
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Evolution of protein trafficking in kinetoplastid parasites : complexity and pathogenesis. / Venkatesh, Divya; Zhang, Ning; Zoltner, Martin; Canavate Del Pino, Ricardo; Field, Mark C. (Lead / Corresponding author).
In: Traffic, Vol. 19, No. 11, 11.2018, p. 803-812.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Evolution of protein trafficking in kinetoplastid parasites
T2 - complexity and pathogenesis
AU - Venkatesh, Divya
AU - Zhang, Ning
AU - Zoltner, Martin
AU - Canavate Del Pino, Ricardo
AU - Field, Mark C.
N1 - Work in the authors’ laboratory is supported by the Wellcome Trust (Investigator award 204697/Z/16/Z) and the Medical Research Council (Project grants MR/N010558/1, MR/K008749/1, MR/P009018/1), which we gratefully acknowledge.
PY - 2018/11
Y1 - 2018/11
N2 - The kinetoplastida and their close relatives are unicellular organisms prevalent within the eukaryotic biosphere and important for significant impacts on global health, economy and ecosystems. They are, under most models, an early branching lineage. Individual species adapted to highly diverse environments by adopting complex life styles; parasitic species can infect a wide range of eukaryotic hosts, while many relatives are free-living and some autotrophic from acquiring a plastid for photosynthesis. Adaptation is especially evident in the evolution of kinetoplastid cell surface architecture and is supported by endomembrane trafficking and serves as a platform for interaction with environment. Here we summarize and discuss recent genomic and experimental studies of the protein trafficking system in kinetoplastids, with focus on the composition and function of the surface as well as mechanisms for constructing, maintaining and regulating the cell surface proteome. We hope this provides a broad view of how protein trafficking contributes to the intricate and dynamic host-parasite interfaces that are critical for successful environmental adaptation of this highly important lineage. This article is protected by copyright. All rights reserved.
AB - The kinetoplastida and their close relatives are unicellular organisms prevalent within the eukaryotic biosphere and important for significant impacts on global health, economy and ecosystems. They are, under most models, an early branching lineage. Individual species adapted to highly diverse environments by adopting complex life styles; parasitic species can infect a wide range of eukaryotic hosts, while many relatives are free-living and some autotrophic from acquiring a plastid for photosynthesis. Adaptation is especially evident in the evolution of kinetoplastid cell surface architecture and is supported by endomembrane trafficking and serves as a platform for interaction with environment. Here we summarize and discuss recent genomic and experimental studies of the protein trafficking system in kinetoplastids, with focus on the composition and function of the surface as well as mechanisms for constructing, maintaining and regulating the cell surface proteome. We hope this provides a broad view of how protein trafficking contributes to the intricate and dynamic host-parasite interfaces that are critical for successful environmental adaptation of this highly important lineage. This article is protected by copyright. All rights reserved.
KW - Endomembrane system
KW - evolution
KW - trypanosomes
KW - kinetoplastida
KW - parasitism
KW - plasma membrane
KW - endocytosis
KW - pathogenesis
KW - drug mode of action
KW - endomembrane system
UR - http://www.scopus.com/inward/record.url?scp=85054834809&partnerID=8YFLogxK
U2 - 10.1111/tra.12601
DO - 10.1111/tra.12601
M3 - Review article
C2 - 29974581
VL - 19
SP - 803
EP - 812
JO - Traffic
JF - Traffic
SN - 1398-9219
IS - 11
ER -