Evolutionary cell biology: two origins, one objective

Michael Lynch (Lead / Corresponding author), Mark C. Field, Holly V. Goodson, Harmit S. Malik, José B. Pereira-Leal, David S. Roos, Aaron P. Turkewitz, Shelley Sazer (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    60 Citations (Scopus)

    Abstract

    All aspects of biological diversification ultimately trace to evolutionary modifications at the cellular level. This central role of cells frames the basic questions as to how cells work and how cells come to be the way they are. Although these two lines of inquiry lie respectively within the traditional provenance of cell biology and evolutionary biology, a comprehensive synthesis of evolutionary and cell-biological thinking is lacking. We define evolutionary cell biology as the fusion of these two eponymous fields with the theoretical and quantitative branches of biochemistry, biophysics, and population genetics. The key goals are to develop a mechanistic understanding of general evolutionary processes, while specifically infusing cell biology with an evolutionary perspective. The full development of this interdisciplinary field has the potential to solve numerous problems in diverse areas of biology, including the degree to which selection, effectively neutral processes, historical contingencies, and/or constraints at the chemical and biophysical levels dictate patterns of variation for intracellular features. These problems can now be examined at both the within- and among-species levels, with single-cell methodologies even allowing quantification of variation within genotypes. Some results from this emerging field have already had a substantial impact on cell biology, and future findings will significantly influence applications in agriculture, medicine, environmental science, and synthetic biology.

    Original languageEnglish
    Pages (from-to)16990-16994
    Number of pages5
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume111
    Issue number48
    DOIs
    Publication statusPublished - 2 Dec 2014

    Keywords

    • Adaptive evolution
    • Cell biology
    • Cellular evolution
    • Evolutionary cell biology
    • Random genetic drift

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