Exercise-induced left ventricular dysfunction in alcoholic and non-alcoholic cirrhosis

Roderick D. Grose, James Nolan, John F. Dillon, Martin Errington, William J. Hannan, Ian A. D. Bouchier, Peter C. Hayes (Lead / Corresponding author)

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    154 Citations (Scopus)


    Background/Aims: Autonomic and cardiac dysfunction have been reported in patients with cirrhosis, We studied left ventricular and autonomic function in 20 patients with both alcoholic and non-alcoholic cirrhosis. Methods: Autonomic function was assessed by a standard battery of cardiovascular reflex tests, Supine exercise radionuclide ventriculography was used to assess the cardiac response to exercise. Results: Exercise capacity was reduced in all patients in association with marked chronotropic incompetence (peak heart rates 120.5±6 bpm), Unlike normal subjects there was no increase in left ventricular ejection fraction on exercise, Stroke volume increased by 23±6%, mediated by an increase in end-diastolic volume of >20%, Cardiac output was subnormal at maximal exercise, increasing by only 96±14% and 97±11% in alcoholic and non-alcoholic groups respectively, The majority (83%) of our patients had autonomic reflex abnormalities. Conclusions: Patients with cirrhosis of alcohol and non-alcohol related aetiologies have significantly impaired cardiovascular responses to exercise, which are similar to those of a denervated heart, This may have important clinical implications for the ability of these patients to withstand cardiovascular stress.
    Original languageEnglish
    Pages (from-to)326-332
    Number of pages7
    JournalJournal of Hepatology
    Issue number3
    Publication statusPublished - 1995


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