Experience with a two-tier reflex gFOBT/FIT strategy in a national bowel screening programme

Callum G. Fraser, Jayne Digby, Paula J. McDonald, Judith A. Strachan, Francis A. Carey, Robert J. C. Steele

    Research output: Contribution to journalArticle

    24 Citations (Scopus)

    Abstract

    Objectives To evaluate a two-tier reflex guaiac-based faecal occult blood test (gFOBT)/faecal immunochemical test (FIT) algorithm in screening for colorectal cancer.

    Setting Fourth screening round in NHS Tayside (Scotland).

    Methods gFOBT were sent to 50-74-year-olds. Participants with five or six windows positive were offered colonoscopy. Participants with one to four windows positive were sent a FIT and, if positive, were offered colonoscopy. Participants providing an untestable gFOBT were sent a FIT and, if positive, were offered colonoscopy. Outcomes following positive results, cancer stages and key performance indicators were assessed.

    Results Of 131,885 invited, 73,315 (55.6%) responded. There were 66,957 (91.3%) negative, 241 (0.3%) strong positive, 5230 (7.1%) weak positive and 887 (1.2%) untestable results. The 241 participants who had five or six windows positive had more cancers than those positive by other routes: only 3 of the 30 cancers (9.7%) were Dukes' A. Among the 983 positive results from the weak positive gFOBT then positive FIT route, there were fewer cancers and more normal colonoscopies, but more adenomas than in the group with a strong positive gFOBT. In those with an untestable gFOBT, 77 had a positive FIT result, with fewer true and more false positive results than in the other groups. Fewer males had cancer and stages were earlier than in females, but more had adenoma. The detection rate for cancer was 0.18% and the PPV for cancer and all adenomas was 41.3%.

    Conclusions The algorithm and FIT following a weak positive gFOBT have advantages. FIT following an untestable gFOBT warrants review.

    Original languageEnglish
    Pages (from-to)8-13
    Number of pages6
    JournalJournal of Medical Screening
    Volume19
    Issue number1
    DOIs
    Publication statusPublished - 2012

    Student Theses

    An analysis of the utility of quantitative faecal immunochemical tests in screening and symptomatic populations

    Author: Mcdonald, P. J., 2016

    Supervisor: Steele, R. (Supervisor) & Bartlett, W. (External person) (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

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