Experimental Assessment of Two Non-Contrast MRI Sequences Used for Computational Fluid Dynamics: Investigation of Consistency Between Techniques

C. J. MacDonald, R. Hellmuth, L. Priba, E. Murphy, S. Gandy, S. Matthew, R. Ross, J. G. Houston (Lead / Corresponding author)

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Abstract

Purpose: Recent studies have noted a degree of variance between the geometries segmented by different groups from 3D medical images that are used in computational fluid dynamics (CFD) simulations of patient-specific cardiovascular systems. The aim of this study was to determine if the applied sequence of magnetic resonance imaging (MRI) also introduced observable variance in CFD results.

Methods: Using a series of phantoms MR images of vessels of known diameter were assessed for the time-of-flight and multi-echo data image combination sequences. Following this, patient images of arterio-venous fistulas were acquired using the same sequences. Comparisons of geometry were made using the phantom and patient images, and of wall shear stress quantities using the CFD results from the patient images.

Results: Phantom images showed deviations in diameter between 0 and 15% between the sequences, depending on vessel diameter. Patient images showed different geometrical features such as narrowings that were not present on both sequences. Distributions of wall shear stress (WSS) quantities differed from simulations between the geometries obtained from the sequences.

Conclusion: In conclusion, choosing different MRI sequences resulted in slightly different geometries of the same anatomy, which led to compounded errors in WSS quantities from CFD simulation.
Original languageEnglish
Pages (from-to)416-430
Number of pages15
JournalCardiovascular Engineering and Technology
Volume11
Issue number4
Early online date1 Jul 2020
DOIs
Publication statusPublished - 1 Aug 2020

Keywords

  • Arterio-venous fistula
  • Computational fluid dynamics
  • Magnetic resonance imaging

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