Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

Ritu S. Sharma, David J. Harrison, Dorothy Kisielewski, Diane M. Cassidy, Alison D. McNeilly, Jennifer R. Gallagher, Shaun V. Walsh, Tadashi Honda, Rory J. McCrimmon, Albena T. Dinkova-Kostova, Michael L. J. Ashford, John F. Dillon, John D. Hayes (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

187 Citations (Scopus)

335 Downloads (Pure)

4 results

Filter

Finished
Contribution by NRF2 Upregulation to Lung Carcinogenesis and the Possible Therapeutic Value of NRF2 Inhibition by GSK-3 (Joint with Universities of St Andrews, Edinburgh and Pennsylvania)
Dinkova-Kostova, A. (Investigator), Hayes, J. (Investigator), Henderson, C. (Investigator), Keyse, S. (Investigator), Lamond, A. (Investigator) & Sutherland, C. (Investigator)
Medical Research Council
1/05/16 → 31/10/19
Project: Research
Targeting the Aspartic Protease BACE1 for Inhibition in Order to Increase Hypothalamic Leptin Sensitivity and Reverse Obesity
Ashford, M. (Investigator)
Medical Research Council
1/01/13 → 31/12/15
Project: Research
Pivotal Role of the Keap1-Nrf2 Pathway in the Pathogenesis and Prevention of Non Alcoholic Steatohepatitis Induced Cirrhosis
Ashford, M. (Investigator), Dillon, J. (Investigator), Hayes, J. (Investigator) & McCrimmon, R. (Investigator)
Medical Research Council
1/11/12 → 31/03/16
Project: Research
Application of Selected-Reaction Monitoring (SRM) Mass Spectrometry for the Global Analysis of the Phosphorylation Status of Protein Kinases
Ashford, M. (Investigator), Dillon, J. (Investigator), Hayes, J. (Investigator), McCrimmon, R. (Investigator) & Trost, M. (Investigator)
Medical Research Council
1/11/12 → 31/03/16
Project: Research