Exploiting barley genetic resources for genomewide association scans (GWAS)

Robbie Waugh (Lead / Corresponding author), Andrew J. Flavell, Joanne Russell, William Bill Thomas, Luke Ramsay, Jordi Comadran

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

We have been exploring the use of GWAS for trait analysis and gene isolation in cultivated barley. In this chapter we describe the approach we have taken and some of the hurdles that we have faced when attempting to establish the whole system. We discuss the way that we, but also others, have addressed the various issues that have arisen and provide guidance on how the can be avoided. These range from choosing the appropriate population for analysis, how to deal with inherent population structure, genetic marker discovery, application and the effect of ascertainment bias to the range of software currently available for conducting association analyses.We conclude by providing a series of successful examples from our laboratory that range from analysis of simple single gene traits through oligogenic to quantitative traits, and the detection of epistatic interactions. We conclude that appropriately designed and executed GWAS in barley is a powerful tool in our quest to identify the genes and alleles underlying key genetic traits.

Original languageEnglish
Title of host publicationGenomics of Plant Genetic Resources: Volume 1. Managing, Sequencing and Mining Genetic Resources
PublisherSpringer Netherlands
Pages237-254
Number of pages18
ISBN (Electronic)9789400775725
ISBN (Print)9789400775718
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Association mapping
  • Barley
  • Germplasm
  • Linkage disequilibrium

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  • Cite this

    Waugh, R., Flavell, A. J., Russell, J., Thomas, W. B., Ramsay, L., & Comadran, J. (2014). Exploiting barley genetic resources for genomewide association scans (GWAS). In Genomics of Plant Genetic Resources: Volume 1. Managing, Sequencing and Mining Genetic Resources (pp. 237-254). Springer Netherlands. https://doi.org/10.1007/978-94-007-7572-5_10