Exploiting the Achilles' heel of membrane trafficking in trypanosomes

Martin Zoltner, David Horn, Harry P. de Koning, Mark C. Field (Lead / Corresponding author)

Research output: Contribution to journalArticle

14 Citations (Scopus)
145 Downloads (Pure)

Abstract

Pathogenic protozoa are evolutionarily highly divergent from their metazoan hosts, reflected in many aspects of their biology. One particularly important parasite taxon is the trypanosomatids. Multiple transmission modes, distinct life cycles and exploitation of many host species attests to great prowess as parasites, and adaptability for efficient, chronic infection. Genome sequencing has begun uncovering how trypanosomatids are well suited to parasitism, and recent genetic screening and cell biology are revealing new aspects of how to control these organisms and prevent disease. Importantly, several lines of evidence suggest that membrane transport processes are central for the sensitivity towards several frontline drugs.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalCurrent Opinion in Microbiology
Volume34
Early online date9 Sep 2016
DOIs
Publication statusPublished - Dec 2016

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