Exploiting the Achilles' heel of membrane trafficking in trypanosomes

Martin Zoltner, David Horn, Harry P. de Koning, Mark C. Field (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)
144 Downloads (Pure)


Pathogenic protozoa are evolutionarily highly divergent from their metazoan hosts, reflected in many aspects of their biology. One particularly important parasite taxon is the trypanosomatids. Multiple transmission modes, distinct life cycles and exploitation of many host species attests to great prowess as parasites, and adaptability for efficient, chronic infection. Genome sequencing has begun uncovering how trypanosomatids are well suited to parasitism, and recent genetic screening and cell biology are revealing new aspects of how to control these organisms and prevent disease. Importantly, several lines of evidence suggest that membrane transport processes are central for the sensitivity towards several frontline drugs.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalCurrent Opinion in Microbiology
Early online date9 Sept 2016
Publication statusPublished - Dec 2016


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