Exploiting the Achilles' heel of membrane trafficking in trypanosomes

Martin Zoltner; David Horn; Harry P. de Koning; Mark C. Field

doi:10.1016/j.mib.2016.08.005

Exploiting the Achilles' heel of membrane trafficking in trypanosomes

Martin Zoltner, David Horn, Harry P. de Koning, Mark C. Field (Lead / Corresponding author)

Biological Chemistry and Drug Discovery

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

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Abstract

Pathogenic protozoa are evolutionarily highly divergent from their metazoan hosts, reflected in many aspects of their biology. One particularly important parasite taxon is the trypanosomatids. Multiple transmission modes, distinct life cycles and exploitation of many host species attests to great prowess as parasites, and adaptability for efficient, chronic infection. Genome sequencing has begun uncovering how trypanosomatids are well suited to parasitism, and recent genetic screening and cell biology are revealing new aspects of how to control these organisms and prevent disease. Importantly, several lines of evidence suggest that membrane transport processes are central for the sensitivity towards several frontline drugs.

Original language	English
Pages (from-to)	97-103
Number of pages	7
Journal	Current Opinion in Microbiology
Volume	34
Early online date	9 Sept 2016
DOIs	https://doi.org/10.1016/j.mib.2016.08.005
Publication status	Published - Dec 2016

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10.1016/j.mib.2016.08.005Licence: CC BY

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© 2016 The Authors. Published by Elsevier Ltd. This article is available under the terms of the Creative Commons Attribution License (CC BY). You may copy and distribute the article, create extracts, abstracts and new works from the article, alter and revise the article, text or data mine the article and otherwise reuse the article commercially (including reuse and/or resale of the article) without permission from Elsevier. You must give appropriate credit to the original work, together with a link to the formal publication through the relevant DOI and a link to the Creative Commons user license above. You must indicate if any changes are made but not in any way that suggests the licensor endorses you or your use of the work. Permission is not required for this type of reuse.
Final published version, 505 KBLicence: CC BY

Chemical Biology: Leveraging Phenotypic Hits Against Kinetoplastids (Strategic Grant)
Fairlamb, A. (Investigator), Field, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator), Horn, D. (Investigator) & Wyatt, P. (Investigator)
1/01/15 → 31/12/20
Project: Research
Melarsoprol-Pentamidine Cross Resistance in African Trypanosomes.
Horn, D. (Investigator)
Medical Research Council
28/10/13 → 27/10/16
Project: Research
High-Throughput Decoding of Virulence Mechanisms in African Trypanosomes (Senior Investigator Award)
Horn, D. (Investigator)
1/09/13 → 29/02/20
Project: Research

Cite this

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title = "Exploiting the Achilles' heel of membrane trafficking in trypanosomes",

abstract = "Pathogenic protozoa are evolutionarily highly divergent from their metazoan hosts, reflected in many aspects of their biology. One particularly important parasite taxon is the trypanosomatids. Multiple transmission modes, distinct life cycles and exploitation of many host species attests to great prowess as parasites, and adaptability for efficient, chronic infection. Genome sequencing has begun uncovering how trypanosomatids are well suited to parasitism, and recent genetic screening and cell biology are revealing new aspects of how to control these organisms and prevent disease. Importantly, several lines of evidence suggest that membrane transport processes are central for the sensitivity towards several frontline drugs.",

author = "Martin Zoltner and David Horn and {de Koning}, {Harry P.} and Field, {Mark C.}",

note = "Funding: MRC (MR/K008749/1 to MCF, MR/K000500/1 to DH, 84733 to HPdK, and MR/L018853/1 to MCF and DH); Wellcome Trust (105021/Z/14/Z to MCF and DH and 100320/Z/12/Z to DH).",

year = "2016",

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doi = "10.1016/j.mib.2016.08.005",

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T1 - Exploiting the Achilles' heel of membrane trafficking in trypanosomes

AU - Zoltner, Martin

AU - Horn, David

AU - de Koning, Harry P.

AU - Field, Mark C.

N1 - Funding: MRC (MR/K008749/1 to MCF, MR/K000500/1 to DH, 84733 to HPdK, and MR/L018853/1 to MCF and DH); Wellcome Trust (105021/Z/14/Z to MCF and DH and 100320/Z/12/Z to DH).

PY - 2016/12

Y1 - 2016/12

N2 - Pathogenic protozoa are evolutionarily highly divergent from their metazoan hosts, reflected in many aspects of their biology. One particularly important parasite taxon is the trypanosomatids. Multiple transmission modes, distinct life cycles and exploitation of many host species attests to great prowess as parasites, and adaptability for efficient, chronic infection. Genome sequencing has begun uncovering how trypanosomatids are well suited to parasitism, and recent genetic screening and cell biology are revealing new aspects of how to control these organisms and prevent disease. Importantly, several lines of evidence suggest that membrane transport processes are central for the sensitivity towards several frontline drugs.

AB - Pathogenic protozoa are evolutionarily highly divergent from their metazoan hosts, reflected in many aspects of their biology. One particularly important parasite taxon is the trypanosomatids. Multiple transmission modes, distinct life cycles and exploitation of many host species attests to great prowess as parasites, and adaptability for efficient, chronic infection. Genome sequencing has begun uncovering how trypanosomatids are well suited to parasitism, and recent genetic screening and cell biology are revealing new aspects of how to control these organisms and prevent disease. Importantly, several lines of evidence suggest that membrane transport processes are central for the sensitivity towards several frontline drugs.

U2 - 10.1016/j.mib.2016.08.005

DO - 10.1016/j.mib.2016.08.005

M3 - Article

C2 - 27614711

SN - 1369-5274

VL - 34

SP - 97

EP - 103

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

ER -

Exploiting the Achilles' heel of membrane trafficking in trypanosomes

Abstract

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Projects

Chemical Biology: Leveraging Phenotypic Hits Against Kinetoplastids (Strategic Grant)

Melarsoprol-Pentamidine Cross Resistance in African Trypanosomes.

High-Throughput Decoding of Virulence Mechanisms in African Trypanosomes (Senior Investigator Award)

Cite this