Exploiting the Achilles' heel of membrane trafficking in trypanosomes

Martin Zoltner, David Horn, Harry P. de Koning, Mark C. Field (Lead / Corresponding author)

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12 Citations (Scopus)
102 Downloads (Pure)

Abstract

Pathogenic protozoa are evolutionarily highly divergent from their metazoan hosts, reflected in many aspects of their biology. One particularly important parasite taxon is the trypanosomatids. Multiple transmission modes, distinct life cycles and exploitation of many host species attests to great prowess as parasites, and adaptability for efficient, chronic infection. Genome sequencing has begun uncovering how trypanosomatids are well suited to parasitism, and recent genetic screening and cell biology are revealing new aspects of how to control these organisms and prevent disease. Importantly, several lines of evidence suggest that membrane transport processes are central for the sensitivity towards several frontline drugs.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalCurrent Opinion in Microbiology
Volume34
Early online date9 Sep 2016
DOIs
Publication statusPublished - Dec 2016

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Trypanosomiasis
Parasites
Membranes
Genetic Testing
Life Cycle Stages
Cell Biology
Genome
Infection
Pharmaceutical Preparations

Cite this

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title = "Exploiting the Achilles' heel of membrane trafficking in trypanosomes",
abstract = "Pathogenic protozoa are evolutionarily highly divergent from their metazoan hosts, reflected in many aspects of their biology. One particularly important parasite taxon is the trypanosomatids. Multiple transmission modes, distinct life cycles and exploitation of many host species attests to great prowess as parasites, and adaptability for efficient, chronic infection. Genome sequencing has begun uncovering how trypanosomatids are well suited to parasitism, and recent genetic screening and cell biology are revealing new aspects of how to control these organisms and prevent disease. Importantly, several lines of evidence suggest that membrane transport processes are central for the sensitivity towards several frontline drugs.",
author = "Martin Zoltner and David Horn and {de Koning}, {Harry P.} and Field, {Mark C.}",
note = "Funding: MRC (MR/K008749/1 to MCF, MR/K000500/1 to DH, 84733 to HPdK, and MR/L018853/1 to MCF and DH); Wellcome Trust (105021/Z/14/Z to MCF and DH and 100320/Z/12/Z to DH).",
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AU - Zoltner, Martin

AU - Horn, David

AU - de Koning, Harry P.

AU - Field, Mark C.

N1 - Funding: MRC (MR/K008749/1 to MCF, MR/K000500/1 to DH, 84733 to HPdK, and MR/L018853/1 to MCF and DH); Wellcome Trust (105021/Z/14/Z to MCF and DH and 100320/Z/12/Z to DH).

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AB - Pathogenic protozoa are evolutionarily highly divergent from their metazoan hosts, reflected in many aspects of their biology. One particularly important parasite taxon is the trypanosomatids. Multiple transmission modes, distinct life cycles and exploitation of many host species attests to great prowess as parasites, and adaptability for efficient, chronic infection. Genome sequencing has begun uncovering how trypanosomatids are well suited to parasitism, and recent genetic screening and cell biology are revealing new aspects of how to control these organisms and prevent disease. Importantly, several lines of evidence suggest that membrane transport processes are central for the sensitivity towards several frontline drugs.

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DO - 10.1016/j.mib.2016.08.005

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JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

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