Exploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growth

Keyphrases

• Cell Growth 100%
• Protein-protein Interface 100%
• Chromosome 2 100%
• Double Minute Chromosomes 100%
• Casein Kinase 2 83%
• Protein-protein Interaction 25%
• Neddylation 25%
• Small Interfering RNA (siRNA) 16%
• Growth Arrest 16%
• Signaling Pathway 8%
• Cell Death 8%
• Binding Site 8%
• Dominant Negative 8%
• Protein Kinase 8%
• Tumor Protein p53 (TP53) 8%
• Pharmacological Inhibitors 8%
• Cell Viability 8%
• Bioactive 8%
• Ubiquitination 8%
• Cell Survival 8%
• Recombinant 8%
• Protein Level 8%
• Genetic Interaction 8%
• Induced Cell Death 8%
• NEDD8 8%
• Ubiquitin 8%
• Pullout 8%
• Ectopic Expression 8%
• P53 Protein 8%
• Novel Types 8%
• RNA-based 8%
• P53-independent 8%
• P53 Activation 8%
• Protein Kinase Signaling 8%
• Binding Motif 8%
• Signaling Events 8%
• Cell Lysate 8%
• Indirect Competitive Enzyme-linked Immunosorbent Assay (icELISA) 8%
• Small Peptides 8%
• Physical Interaction 8%
• Chemical Biology 8%
• Oncoprotein 8%
• Interface Form 8%
• Indirect ELISA 8%
• Overlapping Peptides 8%

Biochemistry, Genetics and Molecular Biology

• Cell Growth 100%
• Phosphotransferase 100%
• Kinase 100%
• Chromosome 2 100%
• Casein Kinase 83%
• Casein Kinase 1 83%
• P53 41%
• Protein-Protein Interaction 25%
• Neddylation 25%
• Cell Death 16%
• Protein Kinases 16%
• Small Interfering RNA 16%
• Genetics 8%
• Binding Site 8%
• Transfection 8%
• Tumor Suppressor Protein 8%
• Cell Lysate 8%
• Cell Viability 8%
• Ubiquitination 8%
• Cell Survival 8%
• Ubiquitin 8%
• NEDD8 8%
• Ectopic Expression 8%

Immunology and Microbiology

• Cell Growth 100%
• Biological Product 100%
• Chromosome 2 100%
• Peptides 50%
• P53 41%
• Protein Protein Interaction 25%
• Neddylation 25%
• Cell Death 16%
• ELISA 16%
• Binding Site 8%
• Cell Viability 8%
• Ubiquitination 8%
• Genetic Transfection 8%
• Ectopic Expression 8%
• Cell Survival 8%
• Cell Lysate 8%
• Ubiquitins 8%