Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles

Vincenza Tinnirello; Nima Rabienezhad Ganji; Carine De Marcos Lousa; Riccardo Alessandro; Stefania Raimondo

doi:10.3390/plants12061207

Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles

Vincenza Tinnirello
, Nima Rabienezhad Ganji
, Carine De Marcos Lousa
, Riccardo Alessandro
, Stefania Raimondo (Lead / Corresponding author)

Drug Discovery Unit

Research output: Contribution to journal › Review article › peer-review

32 Citations (Scopus)

180 Downloads (Pure)

Abstract

The scientific community has become increasingly interested in plant-derived nanoparticles (PDNPs) over the past ten years. Given that they possess all the benefits of a drug carrier, including non-toxicity, low immunogenicity, and a lipid bilayer that protects its content, PDNPs are a viable model for the design of innovative delivery systems. In this review, a summary of the prerequisites for mammalian extracellular vesicles to serve as delivery vehicles will be given. After that, we will concentrate on providing a thorough overview of the studies investigating the interactions of plant-derived nanoparticles with mammalian systems as well as the loading strategies for encapsulating therapeutic molecules. Finally, the existing challenges in establishing PDNPs as reliable biological delivery systems will be emphasized.

Original language	English
Article number	1207
Journal	Plants
Volume	12
Issue number	6
DOIs	https://doi.org/10.3390/plants12061207
Publication status	Published - 7 Mar 2023

Keywords

co-incubation
drug delivery
microRNA
plant-derived nanoparticles (PDNPs)
sonication

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Ecology
Plant Science

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10.3390/plants12061207Licence: CC BY

Final Published VersionFinal published version, 809 KBLicence: CC BY

Cite this

@article{90cec93361704167bbbf551f492711a3,

title = "Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles",

abstract = "The scientific community has become increasingly interested in plant-derived nanoparticles (PDNPs) over the past ten years. Given that they possess all the benefits of a drug carrier, including non-toxicity, low immunogenicity, and a lipid bilayer that protects its content, PDNPs are a viable model for the design of innovative delivery systems. In this review, a summary of the prerequisites for mammalian extracellular vesicles to serve as delivery vehicles will be given. After that, we will concentrate on providing a thorough overview of the studies investigating the interactions of plant-derived nanoparticles with mammalian systems as well as the loading strategies for encapsulating therapeutic molecules. Finally, the existing challenges in establishing PDNPs as reliable biological delivery systems will be emphasized.",

keywords = "co-incubation, drug delivery, microRNA, plant-derived nanoparticles (PDNPs), sonication",

author = "Vincenza Tinnirello and \{Rabienezhad Ganji\}, Nima and \{De Marcos Lousa\}, Carine and Riccardo Alessandro and Stefania Raimondo",

note = "Funding Information: This work was funded by the European Union NextGenerationEU{\textemdash}funds MUR D.M. 737/2021{\textemdash}research project {\textquotedblleft}Effetti anti-infiammatori e vasoprotettivi di vescicole extracellulari isolate da piante{\textquotedblright}, EUROSTART, UNIPA, D.R. 698/2022 to Stefania Raimondo. Stefania Raimondo was supported by PON {\textquotedblleft}Ricerca e Innovazione{\textquotedblright} 2014{\textendash}2020-Azione 1.2 {\textquotedblleft}Mobilit{\`a} dei Ricercatori{\textquotedblright}-AIM {\textquotedblleft}Attraction and International Mobility{\textquotedblright}. Vincenza Tinnirello is PhD student in Biomedicine, Neuroscience and Advanced Diagnostics (XXXVII cycle). Nima Rabienezhad Ganji is a PhD student in Oncology and Experimental Surgery (XXXV cycle), University of Palermo. Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = mar,

day = "7",

doi = "10.3390/plants12061207",

language = "English",

volume = "12",

number = "6",

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T1 - Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles

AU - Tinnirello, Vincenza

AU - Rabienezhad Ganji, Nima

AU - De Marcos Lousa, Carine

AU - Alessandro, Riccardo

AU - Raimondo, Stefania

N1 - Funding Information: This work was funded by the European Union NextGenerationEU—funds MUR D.M. 737/2021—research project “Effetti anti-infiammatori e vasoprotettivi di vescicole extracellulari isolate da piante”, EUROSTART, UNIPA, D.R. 698/2022 to Stefania Raimondo. Stefania Raimondo was supported by PON “Ricerca e Innovazione” 2014–2020-Azione 1.2 “Mobilità dei Ricercatori”-AIM “Attraction and International Mobility”. Vincenza Tinnirello is PhD student in Biomedicine, Neuroscience and Advanced Diagnostics (XXXVII cycle). Nima Rabienezhad Ganji is a PhD student in Oncology and Experimental Surgery (XXXV cycle), University of Palermo. Copyright: © 2023 by the authors.

PY - 2023/3/7

Y1 - 2023/3/7

N2 - The scientific community has become increasingly interested in plant-derived nanoparticles (PDNPs) over the past ten years. Given that they possess all the benefits of a drug carrier, including non-toxicity, low immunogenicity, and a lipid bilayer that protects its content, PDNPs are a viable model for the design of innovative delivery systems. In this review, a summary of the prerequisites for mammalian extracellular vesicles to serve as delivery vehicles will be given. After that, we will concentrate on providing a thorough overview of the studies investigating the interactions of plant-derived nanoparticles with mammalian systems as well as the loading strategies for encapsulating therapeutic molecules. Finally, the existing challenges in establishing PDNPs as reliable biological delivery systems will be emphasized.

AB - The scientific community has become increasingly interested in plant-derived nanoparticles (PDNPs) over the past ten years. Given that they possess all the benefits of a drug carrier, including non-toxicity, low immunogenicity, and a lipid bilayer that protects its content, PDNPs are a viable model for the design of innovative delivery systems. In this review, a summary of the prerequisites for mammalian extracellular vesicles to serve as delivery vehicles will be given. After that, we will concentrate on providing a thorough overview of the studies investigating the interactions of plant-derived nanoparticles with mammalian systems as well as the loading strategies for encapsulating therapeutic molecules. Finally, the existing challenges in establishing PDNPs as reliable biological delivery systems will be emphasized.

KW - co-incubation

KW - drug delivery

KW - microRNA

KW - plant-derived nanoparticles (PDNPs)

KW - sonication

UR - https://www.scopus.com/pages/publications/85151482809

U2 - 10.3390/plants12061207

DO - 10.3390/plants12061207

M3 - Review article

C2 - 36986896

AN - SCOPUS:85151482809

SN - 2223-7747

VL - 12

JO - Plants

JF - Plants

IS - 6

M1 - 1207

ER -

Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles

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Keywords

ASJC Scopus subject areas

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