Exploring the fascinating world of sialoglycans in the interplay with Siglecs

Cristina Di Carluccio; Rosa Ester Forgione; Antonio Molinaro; Paul R. Crocker; Roberta Marchetti; Alba Silipo

doi:10.1039/9781788013864-00031

Exploring the fascinating world of sialoglycans in the interplay with Siglecs

Cristina Di Carluccio, Rosa Ester Forgione, Antonio Molinaro, Paul R. Crocker, Roberta Marchetti, Alba Silipo

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Citations (Scopus)

Abstract

The great relevance of glycans is observable by their molecular and structural heterogeneity that translates into a multiplicity of biological processes which they are involved in. Understanding the role of glycans and glycosylation in immunity is critical to comprehend the etiology and the progression of relevant immune diseases. Siglecs (sialic acid-binding immunoglobulin-like lectins) group a broad range of cell surface immunomodulatory receptors that selectively recognize sialylated glycans, acting as regulators of immune system triggering tolerogenic or immunogenic responses. Here, we provide an overview of the interplay occurring between Siglecs and endogenous as well as exogenous pathogen-derived sialylated glycans, with the final aim of demonstrating the importance of Siglecs-sialoglycan axis in the therapeutic treatment of human diseases.

Original language	English
Title of host publication	Carbohydrate Chemistry
Subtitle of host publication	Chemical and Biological Approaches
Editors	Amelia Pilar Rauter, Thisbe K. Lindhorst, Yves Queneau
Publisher	Royal Society of Chemistry
Pages	31-55
Number of pages	25
ISBN (Electronic)	9781788019248, 9781788013864
ISBN (Print)	9781788013680
DOIs	https://doi.org/10.1039/9781788013864-00031
Publication status	Published - 6 Oct 2020

Publication series

Name	SPR - Carbohydrate Chemistry
Volume	44
ISSN (Print)	2041-353X
ISSN (Electronic)	1465-1963

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/9781788013864-00031

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Di Carluccio, C., Forgione, R. E., Molinaro, A., Crocker, P. R., Marchetti, R., & Silipo, A. (2020). Exploring the fascinating world of sialoglycans in the interplay with Siglecs. In A. P. Rauter, T. K. Lindhorst, & Y. Queneau (Eds.), Carbohydrate Chemistry: Chemical and Biological Approaches (pp. 31-55). (SPR - Carbohydrate Chemistry; Vol. 44). Royal Society of Chemistry. https://doi.org/10.1039/9781788013864-00031

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title = "Exploring the fascinating world of sialoglycans in the interplay with Siglecs",

abstract = "The great relevance of glycans is observable by their molecular and structural heterogeneity that translates into a multiplicity of biological processes which they are involved in. Understanding the role of glycans and glycosylation in immunity is critical to comprehend the etiology and the progression of relevant immune diseases. Siglecs (sialic acid-binding immunoglobulin-like lectins) group a broad range of cell surface immunomodulatory receptors that selectively recognize sialylated glycans, acting as regulators of immune system triggering tolerogenic or immunogenic responses. Here, we provide an overview of the interplay occurring between Siglecs and endogenous as well as exogenous pathogen-derived sialylated glycans, with the final aim of demonstrating the importance of Siglecs-sialoglycan axis in the therapeutic treatment of human diseases. ",

author = "{Di Carluccio}, Cristina and Forgione, {Rosa Ester} and Antonio Molinaro and Crocker, {Paul R.} and Roberta Marchetti and Alba Silipo",

note = "Funding Information: PRIN 2017 {\textquoteleft}{\textquoteleft}Glytunes{\textquoteright}{\textquoteright} (2017XZ2ZBK, 2019-2022) (to AS); progetto POR SATIN and Progetto POR Campania Oncoterapia (to AM); European Research Council (ERC) under the European Union{\textquoteright}s Horizon 2020 research and innovation programme under grant agreement No 851356 (to RM); European Union (FSE, PON Ricerca e Innovazione 2014–2020, Azione I.1 {\textquoteleft}{\textquoteleft}Dottorati Innovativi con caratterizzazione Industriale{\textquoteright}{\textquoteright}) for funding the Ph.D. grant to R.E.F. {\textcopyright} The Royal Society of Chemistry 2021.",

year = "2020",

month = oct,

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doi = "10.1039/9781788013864-00031",

language = "English",

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series = "SPR - Carbohydrate Chemistry",

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Di Carluccio, C, Forgione, RE, Molinaro, A, Crocker, PR, Marchetti, R & Silipo, A 2020, Exploring the fascinating world of sialoglycans in the interplay with Siglecs. in AP Rauter, TK Lindhorst & Y Queneau (eds), Carbohydrate Chemistry: Chemical and Biological Approaches. SPR - Carbohydrate Chemistry, vol. 44, Royal Society of Chemistry, pp. 31-55. https://doi.org/10.1039/9781788013864-00031

Exploring the fascinating world of sialoglycans in the interplay with Siglecs. / Di Carluccio, Cristina; Forgione, Rosa Ester; Molinaro, Antonio et al.
Carbohydrate Chemistry: Chemical and Biological Approaches. ed. / Amelia Pilar Rauter; Thisbe K. Lindhorst; Yves Queneau. Royal Society of Chemistry, 2020. p. 31-55 (SPR - Carbohydrate Chemistry; Vol. 44).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

TY - CHAP

T1 - Exploring the fascinating world of sialoglycans in the interplay with Siglecs

AU - Di Carluccio, Cristina

AU - Forgione, Rosa Ester

AU - Molinaro, Antonio

AU - Crocker, Paul R.

AU - Marchetti, Roberta

AU - Silipo, Alba

N1 - Funding Information: PRIN 2017 ‘‘Glytunes’’ (2017XZ2ZBK, 2019-2022) (to AS); progetto POR SATIN and Progetto POR Campania Oncoterapia (to AM); European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 851356 (to RM); European Union (FSE, PON Ricerca e Innovazione 2014–2020, Azione I.1 ‘‘Dottorati Innovativi con caratterizzazione Industriale’’) for funding the Ph.D. grant to R.E.F. © The Royal Society of Chemistry 2021.

PY - 2020/10/6

Y1 - 2020/10/6

N2 - The great relevance of glycans is observable by their molecular and structural heterogeneity that translates into a multiplicity of biological processes which they are involved in. Understanding the role of glycans and glycosylation in immunity is critical to comprehend the etiology and the progression of relevant immune diseases. Siglecs (sialic acid-binding immunoglobulin-like lectins) group a broad range of cell surface immunomodulatory receptors that selectively recognize sialylated glycans, acting as regulators of immune system triggering tolerogenic or immunogenic responses. Here, we provide an overview of the interplay occurring between Siglecs and endogenous as well as exogenous pathogen-derived sialylated glycans, with the final aim of demonstrating the importance of Siglecs-sialoglycan axis in the therapeutic treatment of human diseases.

AB - The great relevance of glycans is observable by their molecular and structural heterogeneity that translates into a multiplicity of biological processes which they are involved in. Understanding the role of glycans and glycosylation in immunity is critical to comprehend the etiology and the progression of relevant immune diseases. Siglecs (sialic acid-binding immunoglobulin-like lectins) group a broad range of cell surface immunomodulatory receptors that selectively recognize sialylated glycans, acting as regulators of immune system triggering tolerogenic or immunogenic responses. Here, we provide an overview of the interplay occurring between Siglecs and endogenous as well as exogenous pathogen-derived sialylated glycans, with the final aim of demonstrating the importance of Siglecs-sialoglycan axis in the therapeutic treatment of human diseases.

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DO - 10.1039/9781788013864-00031

M3 - Chapter

AN - SCOPUS:85094169442

SN - 9781788013680

T3 - SPR - Carbohydrate Chemistry

SP - 31

EP - 55

BT - Carbohydrate Chemistry

A2 - Rauter, Amelia Pilar

A2 - Lindhorst, Thisbe K.

A2 - Queneau, Yves

PB - Royal Society of Chemistry

ER -

Di Carluccio C, Forgione RE, Molinaro A, Crocker PR, Marchetti R, Silipo A. Exploring the fascinating world of sialoglycans in the interplay with Siglecs. In Rauter AP, Lindhorst TK, Queneau Y, editors, Carbohydrate Chemistry: Chemical and Biological Approaches. Royal Society of Chemistry. 2020. p. 31-55. (SPR - Carbohydrate Chemistry). doi: 10.1039/9781788013864-00031

Exploring the fascinating world of sialoglycans in the interplay with Siglecs

Abstract

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