Exploring the fascinating world of sialoglycans in the interplay with Siglecs

Cristina Di Carluccio, Rosa Ester Forgione, Antonio Molinaro, Paul R. Crocker, Roberta Marchetti, Alba Silipo

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    The great relevance of glycans is observable by their molecular and structural heterogeneity that translates into a multiplicity of biological processes which they are involved in. Understanding the role of glycans and glycosylation in immunity is critical to comprehend the etiology and the progression of relevant immune diseases. Siglecs (sialic acid-binding immunoglobulin-like lectins) group a broad range of cell surface immunomodulatory receptors that selectively recognize sialylated glycans, acting as regulators of immune system triggering tolerogenic or immunogenic responses. Here, we provide an overview of the interplay occurring between Siglecs and endogenous as well as exogenous pathogen-derived sialylated glycans, with the final aim of demonstrating the importance of Siglecs-sialoglycan axis in the therapeutic treatment of human diseases.

    Original languageEnglish
    Title of host publicationCarbohydrate Chemistry
    Subtitle of host publicationChemical and Biological Approaches
    EditorsAmelia Pilar Rauter, Thisbe K. Lindhorst, Yves Queneau
    PublisherRoyal Society of Chemistry
    Pages31-55
    Number of pages25
    ISBN (Electronic)9781788019248, 9781788013864
    ISBN (Print)9781788013680
    DOIs
    Publication statusPublished - 6 Oct 2020

    Publication series

    NameSPR - Carbohydrate Chemistry
    Volume44
    ISSN (Print)2041-353X
    ISSN (Electronic)1465-1963

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