Exploring the Function of Dynamic Phosphorylation-Dephosphorylation Cycles

Lendert Gelens; Adrian T. Saurin

doi:10.1016/j.devcel.2018.03.002

Exploring the Function of Dynamic Phosphorylation-Dephosphorylation Cycles

Lendert Gelens, Adrian T. Saurin (Lead / Corresponding author)

Research output: Contribution to journal › Comment/debate › peer-review

42 Citations (Scopus)

Abstract

Protein phosphorylation is a dynamic post-translational modification critical for biological responses. At the level of individual molecules, phosphorylation dynamics can have important functional implications, but this information is rarely quantified. We discuss how rapid phosphorylation-dephosphorylation cycles could underlie important signaling properties, including the ability to rapidly bind and release proteins.

Original language	English
Pages (from-to)	659-663
Number of pages	5
Journal	Developmental Cell
Volume	44
Issue number	6
DOIs	https://doi.org/10.1016/j.devcel.2018.03.002
Publication status	Published - 26 Mar 2018

ASJC Scopus subject areas

Developmental Biology

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10.1016/j.devcel.2018.03.002Licence: Elsevier User Licence

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title = "Exploring the Function of Dynamic Phosphorylation-Dephosphorylation Cycles",

abstract = "Protein phosphorylation is a dynamic post-translational modification critical for biological responses. At the level of individual molecules, phosphorylation dynamics can have important functional implications, but this information is rarely quantified. We discuss how rapid phosphorylation-dephosphorylation cycles could underlie important signaling properties, including the ability to rapidly bind and release proteins.",

author = "Lendert Gelens and Saurin, {Adrian T.}",

note = "A.T.S. is funded by Cancer Research UK (Programme Foundation Award C47320/A21229), and L.G. acknowledges support from research foundation Flanders (FWO-Vlaanderen; G0A5217N) and Internal Funds of KU Leuven.",

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AU - Saurin, Adrian T.

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PY - 2018/3/26

Y1 - 2018/3/26

N2 - Protein phosphorylation is a dynamic post-translational modification critical for biological responses. At the level of individual molecules, phosphorylation dynamics can have important functional implications, but this information is rarely quantified. We discuss how rapid phosphorylation-dephosphorylation cycles could underlie important signaling properties, including the ability to rapidly bind and release proteins.

AB - Protein phosphorylation is a dynamic post-translational modification critical for biological responses. At the level of individual molecules, phosphorylation dynamics can have important functional implications, but this information is rarely quantified. We discuss how rapid phosphorylation-dephosphorylation cycles could underlie important signaling properties, including the ability to rapidly bind and release proteins.

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DO - 10.1016/j.devcel.2018.03.002

M3 - Comment/debate

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SN - 1534-5807

VL - 44

SP - 659

EP - 663

JO - Developmental Cell

JF - Developmental Cell

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ER -

Exploring the Function of Dynamic Phosphorylation-Dephosphorylation Cycles

Abstract

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