Exploring the Function of Dynamic Phosphorylation-Dephosphorylation Cycles

Lendert Gelens, Adrian T. Saurin (Lead / Corresponding author)

    Research output: Contribution to journalComment/debatepeer-review

    23 Citations (Scopus)

    Abstract

    Protein phosphorylation is a dynamic post-translational modification critical for biological responses. At the level of individual molecules, phosphorylation dynamics can have important functional implications, but this information is rarely quantified. We discuss how rapid phosphorylation-dephosphorylation cycles could underlie important signaling properties, including the ability to rapidly bind and release proteins.

    Original languageEnglish
    Pages (from-to)659-663
    Number of pages5
    JournalDevelopmental Cell
    Volume44
    Issue number6
    DOIs
    Publication statusPublished - 26 Mar 2018

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