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Abstract
Type 2 diabetes (T2D) is a complex condition characterised by the interaction between insulin resistance and beta cell dysfunction. C-peptide, a key biomarker of endogenous insulin secretion, has a role in diagnosing type 1 diabetes (T1D). However, its utility in T2D has not been extensively studied. This review provides an overview of the progression of C-peptide levels over time in T2D and discuss its interpretation in clinical settings. We reviewed current evidence on the relationship between C-peptide levels and response to antidiabetic drugs, as well as the utility of C-peptide testing in T2D treatment strategies. We also reviewed available evidence for C-peptide in predicting future outcomes in T2D. In this review, we hoped to clarify the value of C-peptide testing in understanding and managing T2D and to highlight areas where further research is needed.
| Original language | English |
|---|---|
| Article number | e15469 |
| Journal | Diabetic Medicine |
| Early online date | 11 Jan 2025 |
| DOIs | |
| Publication status | E-pub ahead of print - 11 Jan 2025 |
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Dive into the research topics of 'Exploring the potential role of C‐peptide in type 2 diabetes management'. Together they form a unique fingerprint.Projects
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The iDiabetes Platform - Enhanced Phenotyping of Patients With Diabetes For Precision Diagnosis, Prognosis and Treatment (Joint with NHS Education for Scotland and University of Aberdeen)
Bell, S. (Investigator), Croudace, T. (Investigator), Cunningham, S. (Investigator), Dillon, J. (Investigator), Doney, A. (Investigator), Donnan, P. (Investigator), Farre, A. (Investigator), Lang, C. (Investigator), McCrimmon, R. (Investigator), Mordi, I. (Investigator), Palmer, C. (Investigator) & Pearson, E. (Investigator)
1/05/22 → 31/12/27
Project: Research