Abstract
BACKGROUND: P53, a crucial suppressor of tumor formation, generates multiple isoforms, whose role in disease is still being defined.
METHODS: By immunohistochemistry, we studied the expression of P53 protein and relative isoforms in benign papillomas (PA, n=9), inverted papilloma (IPA, n=10) and squamous cell carcinomas (SCC, n=21).
RESULTS: In all lesions, P53 isoforms were significantly more expressed than P53. Immunoexpression of P53 matched with P53 isoforms in IPA as well as in SCC. Simultaneous immune-expression of P53 and related isoforms was double in SCC compared to IPA (10% vs 24%), while expression of P53 isoforms was strongly reduced (70% vs 43%). IPA showed the highest percentage of both reactive cases and immunostained cells expressing P53 isoforms.
CONCLUSIONS: We found the higher expression of P53 isoforms in IPA and SCC compared to PA, suggesting their role in local aggressiveness and malignant proliferation in head-neck lesions.
Original language | English |
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Pages (from-to) | 371-377 |
Number of pages | 7 |
Journal | Histology and Histopathology |
Volume | 32 |
Issue number | 4 |
Early online date | 14 Jul 2016 |
DOIs | |
Publication status | Published - Apr 2017 |
Keywords
- P53
- P53 isoforms
- Immunohistoochemistry
- Benign and malignant squamous lesions
- Head and neck carcinogenesis