Expression of P53 and isoforms in bening and malignant lesions of the head and neck

M. C. Trovato; R. M. Ruggeri; E. Guzzo; R. Certo; A. Alibrandi; S. Scifo; M. Scardigno; E. Vitarelli; G. Arena; O. Gambadoro; N. Catalano; J. C. Bourdon; B. Galletti; F. Galletti; V. Cavallari

doi:10.14670/HH-11-802

Expression of P53 and isoforms in bening and malignant lesions of the head and neck

M. C. Trovato (Lead / Corresponding author)
, R. M. Ruggeri
, E. Guzzo
, R. Certo
, A. Alibrandi
, S. Scifo
, M. Scardigno
, E. Vitarelli
, G. Arena
, O. Gambadoro
, N. Catalano
, J. C. Bourdon
, B. Galletti
, F. Galletti
, V. Cavallari

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

201 Downloads (Pure)

Abstract

BACKGROUND: P53, a crucial suppressor of tumor formation, generates multiple isoforms, whose role in disease is still being defined.

METHODS: By immunohistochemistry, we studied the expression of P53 protein and relative isoforms in benign papillomas (PA, n=9), inverted papilloma (IPA, n=10) and squamous cell carcinomas (SCC, n=21).

RESULTS: In all lesions, P53 isoforms were significantly more expressed than P53. Immunoexpression of P53 matched with P53 isoforms in IPA as well as in SCC. Simultaneous immune-expression of P53 and related isoforms was double in SCC compared to IPA (10% vs 24%), while expression of P53 isoforms was strongly reduced (70% vs 43%). IPA showed the highest percentage of both reactive cases and immunostained cells expressing P53 isoforms.

CONCLUSIONS: We found the higher expression of P53 isoforms in IPA and SCC compared to PA, suggesting their role in local aggressiveness and malignant proliferation in head-neck lesions.

Original language	English
Pages (from-to)	371-377
Number of pages	7
Journal	Histology and Histopathology
Volume	32
Issue number	4
Early online date	14 Jul 2016
DOIs	https://doi.org/10.14670/HH-11-802
Publication status	Published - Apr 2017

Keywords

P53
P53 isoforms
Immunohistoochemistry
Benign and malignant squamous lesions
Head and neck carcinogenesis

Access to Document

10.14670/HH-11-802

Author Accepted ManuscriptAccepted author manuscript, 1.31 MB

Cite this

Trovato, M. C., Ruggeri, R. M., Guzzo, E., Certo, R., Alibrandi, A., Scifo, S., Scardigno, M., Vitarelli, E., Arena, G., Gambadoro, O., Catalano, N., Bourdon, J. C., Galletti, B., Galletti, F., & Cavallari, V. (2017). Expression of P53 and isoforms in bening and malignant lesions of the head and neck. Histology and Histopathology, 32(4), 371-377. https://doi.org/10.14670/HH-11-802

@article{e0a5e20ee4c5421b813c84641ab954dc,

title = "Expression of P53 and isoforms in bening and malignant lesions of the head and neck",

abstract = "BACKGROUND: P53, a crucial suppressor of tumor formation, generates multiple isoforms, whose role in disease is still being defined.METHODS: By immunohistochemistry, we studied the expression of P53 protein and relative isoforms in benign papillomas (PA, n=9), inverted papilloma (IPA, n=10) and squamous cell carcinomas (SCC, n=21).RESULTS: In all lesions, P53 isoforms were significantly more expressed than P53. Immunoexpression of P53 matched with P53 isoforms in IPA as well as in SCC. Simultaneous immune-expression of P53 and related isoforms was double in SCC compared to IPA (10\% vs 24\%), while expression of P53 isoforms was strongly reduced (70\% vs 43\%). IPA showed the highest percentage of both reactive cases and immunostained cells expressing P53 isoforms.CONCLUSIONS: We found the higher expression of P53 isoforms in IPA and SCC compared to PA, suggesting their role in local aggressiveness and malignant proliferation in head-neck lesions.",

keywords = "P53, P53 isoforms, Immunohistoochemistry, Benign and malignant squamous lesions, Head and neck carcinogenesis",

author = "Trovato, \{M. C.\} and Ruggeri, \{R. M.\} and E. Guzzo and R. Certo and A. Alibrandi and S. Scifo and M. Scardigno and E. Vitarelli and G. Arena and O. Gambadoro and N. Catalano and Bourdon, \{J. C.\} and B. Galletti and F. Galletti and V. Cavallari",

year = "2017",

month = apr,

doi = "10.14670/HH-11-802",

language = "English",

volume = "32",

pages = "371--377",

journal = "Histology and Histopathology",

issn = "0213-3911",

publisher = "Histology and Histopathology",

number = "4",

}

Trovato, MC, Ruggeri, RM, Guzzo, E, Certo, R, Alibrandi, A, Scifo, S, Scardigno, M, Vitarelli, E, Arena, G, Gambadoro, O, Catalano, N, Bourdon, JC, Galletti, B, Galletti, F & Cavallari, V 2017, 'Expression of P53 and isoforms in bening and malignant lesions of the head and neck', Histology and Histopathology, vol. 32, no. 4, pp. 371-377. https://doi.org/10.14670/HH-11-802

TY - JOUR

T1 - Expression of P53 and isoforms in bening and malignant lesions of the head and neck

AU - Trovato, M. C.

AU - Ruggeri, R. M.

AU - Guzzo, E.

AU - Certo, R.

AU - Alibrandi, A.

AU - Scifo, S.

AU - Scardigno, M.

AU - Vitarelli, E.

AU - Arena, G.

AU - Gambadoro, O.

AU - Catalano, N.

AU - Bourdon, J. C.

AU - Galletti, B.

AU - Galletti, F.

AU - Cavallari, V.

PY - 2017/4

Y1 - 2017/4

N2 - BACKGROUND: P53, a crucial suppressor of tumor formation, generates multiple isoforms, whose role in disease is still being defined.METHODS: By immunohistochemistry, we studied the expression of P53 protein and relative isoforms in benign papillomas (PA, n=9), inverted papilloma (IPA, n=10) and squamous cell carcinomas (SCC, n=21).RESULTS: In all lesions, P53 isoforms were significantly more expressed than P53. Immunoexpression of P53 matched with P53 isoforms in IPA as well as in SCC. Simultaneous immune-expression of P53 and related isoforms was double in SCC compared to IPA (10% vs 24%), while expression of P53 isoforms was strongly reduced (70% vs 43%). IPA showed the highest percentage of both reactive cases and immunostained cells expressing P53 isoforms.CONCLUSIONS: We found the higher expression of P53 isoforms in IPA and SCC compared to PA, suggesting their role in local aggressiveness and malignant proliferation in head-neck lesions.

AB - BACKGROUND: P53, a crucial suppressor of tumor formation, generates multiple isoforms, whose role in disease is still being defined.METHODS: By immunohistochemistry, we studied the expression of P53 protein and relative isoforms in benign papillomas (PA, n=9), inverted papilloma (IPA, n=10) and squamous cell carcinomas (SCC, n=21).RESULTS: In all lesions, P53 isoforms were significantly more expressed than P53. Immunoexpression of P53 matched with P53 isoforms in IPA as well as in SCC. Simultaneous immune-expression of P53 and related isoforms was double in SCC compared to IPA (10% vs 24%), while expression of P53 isoforms was strongly reduced (70% vs 43%). IPA showed the highest percentage of both reactive cases and immunostained cells expressing P53 isoforms.CONCLUSIONS: We found the higher expression of P53 isoforms in IPA and SCC compared to PA, suggesting their role in local aggressiveness and malignant proliferation in head-neck lesions.

KW - P53

KW - P53 isoforms

KW - Immunohistoochemistry

KW - Benign and malignant squamous lesions

KW - Head and neck carcinogenesis

U2 - 10.14670/HH-11-802

DO - 10.14670/HH-11-802

M3 - Article

C2 - 27411919

SN - 0213-3911

VL - 32

SP - 371

EP - 377

JO - Histology and Histopathology

JF - Histology and Histopathology

IS - 4

ER -

Expression of P53 and isoforms in bening and malignant lesions of the head and neck

Abstract

Keywords

Access to Document

Fingerprint

Cite this