Expression of the 'Dead Box' RNA Helicase p68 is developmentally and growth regulated and correlates with organ differentiation/maturation in the fetus

Rebecca J. Stevenson, Stuart J. Hamilton, David E. MacCallum, Peter A. Hall, Frances V. Fuller-Pace (Lead / Corresponding author)

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    96 Citations (Scopus)

    Abstract

    The human DEAD box protein p68 is an established RNA-dependent ATPase and RNA helicase. p68 has been highly conserved in evolution and appears to be essential for normal growth, suggesting that this protein plays an important role in the cell. Although the biochemical activities of p68 are fairly well characterized, little is known about its biological function. This report shows that p68 is detectable in quiescent cell lines, but its expression is induced by serum, suggesting that this protein may play a role in cell growth. It is also shown that both p68 mRNA and protein are differentially expressed in adult tissues; in this case, however, the levels do not always correlate with proliferation status, suggesting that the regulation of expression in the animal may be different from that in cell lines. Finally, it is shown that p68 expression is developmentally regulated and appears to correlate with organ differentiation/maturation. These findings suggest that p68 expression may not simply reflect proliferation/differentiation status and that it appears to be regulated in a more complex way. ;.("1998 John Wiley & Sons, Ltd.

    Original languageEnglish
    Pages (from-to)351-359
    Number of pages9
    JournalJournal of Pathology
    Volume184
    Issue number4
    DOIs
    Publication statusPublished - Apr 1998

    Keywords

    • Cell growth
    • Development
    • Differentiation
    • p68 dead box protein

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