Expression of the smn splicing protein is developmentally regulated in the rodent brain but not in the rodent heart

K. Grimaldi; D. A. Horn; L. D. Hudson; G. Terenghi; P. Barton; J. M. Polar; D. S. Latchman

doi:10.1006/dbio.1993.1080

Expression of the smn splicing protein is developmentally regulated in the rodent brain but not in the rodent heart

K. Grimaldi, D. A. Horn, L. D. Hudson, G. Terenghi, P. Barton, J. M. Polar, D. S. Latchman

Biological Chemistry and Drug Discovery

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The SmN protein is a tissue-specific splicing factor which is closely related to the ubiquitous SmB splicing protein but which is expressed only in the adult brain and heart. SmN is also detectable albeit at a low level in both the embryonic brain and heart. During heart development, SmN levels remain constant while during rodent brain development the levels of SmN rise such that SmN replaces SmB as the predominant protein in adult brain. This increase in SmN levels is dependent upon a corresponding increase in the SmN mRNA which is detectable by in situ hybridization within neurons in virtually all areas of the adult brain.

Original language	English
Pages (from-to)	319-323
Number of pages	5
Journal	Developmental Biology
Volume	156
Issue number	2
DOIs	https://doi.org/10.1006/dbio.1993.1080
Publication status	Published - Apr 1993

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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10.1006/dbio.1993.1080

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title = "Expression of the smn splicing protein is developmentally regulated in the rodent brain but not in the rodent heart",

abstract = "The SmN protein is a tissue-specific splicing factor which is closely related to the ubiquitous SmB splicing protein but which is expressed only in the adult brain and heart. SmN is also detectable albeit at a low level in both the embryonic brain and heart. During heart development, SmN levels remain constant while during rodent brain development the levels of SmN rise such that SmN replaces SmB as the predominant protein in adult brain. This increase in SmN levels is dependent upon a corresponding increase in the SmN mRNA which is detectable by in situ hybridization within neurons in virtually all areas of the adult brain.",

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AU - Horn, D. A.

AU - Hudson, L. D.

AU - Terenghi, G.

AU - Barton, P.

AU - Polar, J. M.

AU - Latchman, D. S.

PY - 1993/4

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AB - The SmN protein is a tissue-specific splicing factor which is closely related to the ubiquitous SmB splicing protein but which is expressed only in the adult brain and heart. SmN is also detectable albeit at a low level in both the embryonic brain and heart. During heart development, SmN levels remain constant while during rodent brain development the levels of SmN rise such that SmN replaces SmB as the predominant protein in adult brain. This increase in SmN levels is dependent upon a corresponding increase in the SmN mRNA which is detectable by in situ hybridization within neurons in virtually all areas of the adult brain.

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Expression of the smn splicing protein is developmentally regulated in the rodent brain but not in the rodent heart

Abstract

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