Expression quantitative trait loci analysis in plants

Arnis Druka, Elena Potokina, Zewei Luo, Ning Jiang, Xinwei Chen, Mike Kearsey, Robbie Waugh

    Research output: Contribution to journalArticlepeer-review

    80 Citations (Scopus)
    199 Downloads (Pure)


    An expression Quantitative Trait Locus or eQTL is a chromosomal region that accounts for a proportion of the variation in abundance of a mRNA transcript observed between individuals in a genetic mapping population. A single gene can have one or multiple eQTLs. Large scale mRNA profiling technologies advanced genome-wide eQTL mapping in a diverse range of organisms allowing thousands of eQTLs to be detected in a single experiment. When combined with classical or trait QTLs, correlation analyses can directly suggest candidates for genes underlying these traits. Furthermore, eQTL mapping data enables genetic regulatory networks to be modelled and potentially provide a better understanding of the underlying phenotypic variation. The mRNA profiling data sets can also be used to infer the chromosomal positions of thousands of genes, an outcome that is particularly valuable for species with unsequenced genomes where the chromosomal location of the majority of genes remains unknown. In this review we focus on eQTL studies in plants, addressing conceptual and technical aspects that include experimental design, genetic polymorphism prediction and candidate gene identification.

    Original languageEnglish
    Pages (from-to)10-27
    Number of pages18
    JournalPlant Biotechnology Journal
    Issue number1
    Publication statusPublished - Jan 2010


    • Expression quantitative trait loci
    • Genetical genomics
    • Transcript-derived markers
    • Transcript-level variation

    ASJC Scopus subject areas

    • Biotechnology
    • Agronomy and Crop Science
    • Plant Science


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