TY - CHAP
T1 - External anogenital premalignant and malignant disease
AU - Gibbon, K.L.
AU - Ekeowa-Anderson, A.L.
AU - Leigh, I.M.
PY - 2009
Y1 - 2009
N2 - The external anogenital area comprises the anus, perianal skin, and the adjacent external genitalia including the vulva and vaginal introitus in the female, and the penis and scrotum in the male. Immunosuppressed organ transplant recipients (OTR) are prone to viral infections, and have an increased incidence of human papillomavirus (HPV) associated premalignant and malignant neoplasms, which specifically target the anogenital tract. The cumulative risk of the development of a solid-organ neoplasm is 5-6% [1-3]. Nearly all of these neoplasms occur on a background of premalignant disease (i.e., carcinoma in situ). The most common presentation of anogenital disease in OTR is condyloma accuminata or genital viral warts and these are regarded as a marker of immunosuppression in this group.
AB - The external anogenital area comprises the anus, perianal skin, and the adjacent external genitalia including the vulva and vaginal introitus in the female, and the penis and scrotum in the male. Immunosuppressed organ transplant recipients (OTR) are prone to viral infections, and have an increased incidence of human papillomavirus (HPV) associated premalignant and malignant neoplasms, which specifically target the anogenital tract. The cumulative risk of the development of a solid-organ neoplasm is 5-6% [1-3]. Nearly all of these neoplasms occur on a background of premalignant disease (i.e., carcinoma in situ). The most common presentation of anogenital disease in OTR is condyloma accuminata or genital viral warts and these are regarded as a marker of immunosuppression in this group.
UR - http://www.scopus.com/inward/record.url?scp=77953669200&partnerID=8YFLogxK
U2 - 10.1007/978-0-387-78574-5_23
DO - 10.1007/978-0-387-78574-5_23
M3 - Other chapter contribution
C2 - 19415210
AN - SCOPUS:77953669200
VL - 146
T3 - Cancer Treatment and Research
SP - 279
EP - 298
BT - Skin Cancer after Organ Transplantation
A2 - Stockfleth, Eggert
A2 - Ulrich, Claas
A2 - Euvrard, Sylvie
A2 - Proby, Charlotte
A2 - Bavinck, Jan-Nico Bouwes
A2 - Geissler, Edward K.
PB - Springer
ER -