External anogenital premalignant and malignant disease

K.L. Gibbon, A.L. Ekeowa-Anderson, I.M. Leigh

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution


    The external anogenital area comprises the anus, perianal skin, and the adjacent external genitalia including the vulva and vaginal introitus in the female, and the penis and scrotum in the male. Immunosuppressed organ transplant recipients (OTR) are prone to viral infections, and have an increased incidence of human papillomavirus (HPV) associated premalignant and malignant neoplasms, which specifically target the anogenital tract. The cumulative risk of the development of a solid-organ neoplasm is 5-6% [1-3]. Nearly all of these neoplasms occur on a background of premalignant disease (i.e., carcinoma in situ). The most common presentation of anogenital disease in OTR is condyloma accuminata or genital viral warts and these are regarded as a marker of immunosuppression in this group.
    Original languageEnglish
    Title of host publicationSkin Cancer after Organ Transplantation
    EditorsEggert Stockfleth, Claas Ulrich, Sylvie Euvrard, Charlotte Proby, Jan-Nico Bouwes Bavinck, Edward K. Geissler
    Number of pages20
    ISBN (Electronic)9780387785745
    Publication statusPublished - 2009

    Publication series

    NameCancer Treatment and Research
    ISSN (Print)0927-3042


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