The external anogenital area comprises the anus, perianal skin, and the adjacent external genitalia including the vulva and vaginal introitus in the female, and the penis and scrotum in the male. Immunosuppressed organ transplant recipients (OTR) are prone to viral infections, and have an increased incidence of human papillomavirus (HPV) associated premalignant and malignant neoplasms, which specifically target the anogenital tract. The cumulative risk of the development of a solid-organ neoplasm is 5-6% [1-3]. Nearly all of these neoplasms occur on a background of premalignant disease (i.e., carcinoma in situ). The most common presentation of anogenital disease in OTR is condyloma accuminata or genital viral warts and these are regarded as a marker of immunosuppression in this group.
|Title of host publication||Skin Cancer after Organ Transplantation|
|Editors||Eggert Stockfleth, Claas Ulrich, Sylvie Euvrard, Charlotte Proby, Jan-Nico Bouwes Bavinck, Edward K. Geissler|
|Number of pages||20|
|Publication status||Published - 2009|
|Name||Cancer Treatment and Research|