Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

Jian Song, Zerina Lokmic, Tim Lämmermann, Julia Rolf, Chuan Wu, Xueli Zhang, Rupert Hallmann, Melanie-Jane Hannocks, Nathalie Horn, Markus A. Ruegg, Arnoud Sonnenberg, Elisabeth Georges-Labouesse, Thomas H. Winkler, John F. Kearney, Susanna Cardell, Lydia Sorokin

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    45 Citations (Scopus)

    Abstract

    We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin a5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin a5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin a6ß1-mediated interaction of NF B cells with laminin a5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.
    Original languageEnglish
    Pages (from-to)E2915-E2924
    Number of pages10
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume110
    Issue number31
    DOIs
    Publication statusPublished - 2013

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  • Cite this

    Song, J., Lokmic, Z., Lämmermann, T., Rolf, J., Wu, C., Zhang, X., Hallmann, R., Hannocks, M-J., Horn, N., Ruegg, M. A., Sonnenberg, A., Georges-Labouesse, E., Winkler, T. H., Kearney, J. F., Cardell, S., & Sorokin, L. (2013). Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proceedings of the National Academy of Sciences of the United States of America, 110(31), E2915-E2924. https://doi.org/10.1073/pnas.1218131110