Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

Jian Song, Zerina Lokmic, Tim Lämmermann, Julia Rolf, Chuan Wu, Xueli Zhang, Rupert Hallmann, Melanie-Jane Hannocks, Nathalie Horn, Markus A. Ruegg, Arnoud Sonnenberg, Elisabeth Georges-Labouesse, Thomas H. Winkler, John F. Kearney, Susanna Cardell, Lydia Sorokin

    Research output: Contribution to journalArticle

    39 Citations (Scopus)

    Abstract

    We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin a5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin a5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin a6ß1-mediated interaction of NF B cells with laminin a5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.
    Original languageEnglish
    Pages (from-to)E2915-E2924
    Number of pages10
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume110
    Issue number31
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Extracellular Matrix
    Cell Survival
    Laminin
    B-Lymphocytes
    Agrin
    B-Lymphoid Precursor Cells
    Membrane Glycoproteins
    Stromal Cells
    Basement Membrane
    Integrins
    Population
    Antibody Formation
    Spleen
    Cell Count
    Bone Marrow
    Antigens

    Cite this

    Song, Jian ; Lokmic, Zerina ; Lämmermann, Tim ; Rolf, Julia ; Wu, Chuan ; Zhang, Xueli ; Hallmann, Rupert ; Hannocks, Melanie-Jane ; Horn, Nathalie ; Ruegg, Markus A. ; Sonnenberg, Arnoud ; Georges-Labouesse, Elisabeth ; Winkler, Thomas H. ; Kearney, John F. ; Cardell, Susanna ; Sorokin, Lydia. / Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. In: Proceedings of the National Academy of Sciences of the United States of America. 2013 ; Vol. 110, No. 31. pp. E2915-E2924.
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    abstract = "We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin a5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin a5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin a6{\ss}1-mediated interaction of NF B cells with laminin a5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.",
    author = "Jian Song and Zerina Lokmic and Tim L{\"a}mmermann and Julia Rolf and Chuan Wu and Xueli Zhang and Rupert Hallmann and Melanie-Jane Hannocks and Nathalie Horn and Ruegg, {Markus A.} and Arnoud Sonnenberg and Elisabeth Georges-Labouesse and Winkler, {Thomas H.} and Kearney, {John F.} and Susanna Cardell and Lydia Sorokin",
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    Song, J, Lokmic, Z, Lämmermann, T, Rolf, J, Wu, C, Zhang, X, Hallmann, R, Hannocks, M-J, Horn, N, Ruegg, MA, Sonnenberg, A, Georges-Labouesse, E, Winkler, TH, Kearney, JF, Cardell, S & Sorokin, L 2013, 'Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 31, pp. E2915-E2924. https://doi.org/10.1073/pnas.1218131110

    Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. / Song, Jian; Lokmic, Zerina; Lämmermann, Tim; Rolf, Julia; Wu, Chuan; Zhang, Xueli; Hallmann, Rupert; Hannocks, Melanie-Jane; Horn, Nathalie; Ruegg, Markus A.; Sonnenberg, Arnoud; Georges-Labouesse, Elisabeth; Winkler, Thomas H.; Kearney, John F.; Cardell, Susanna; Sorokin, Lydia.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 31, 2013, p. E2915-E2924.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

    AU - Song, Jian

    AU - Lokmic, Zerina

    AU - Lämmermann, Tim

    AU - Rolf, Julia

    AU - Wu, Chuan

    AU - Zhang, Xueli

    AU - Hallmann, Rupert

    AU - Hannocks, Melanie-Jane

    AU - Horn, Nathalie

    AU - Ruegg, Markus A.

    AU - Sonnenberg, Arnoud

    AU - Georges-Labouesse, Elisabeth

    AU - Winkler, Thomas H.

    AU - Kearney, John F.

    AU - Cardell, Susanna

    AU - Sorokin, Lydia

    PY - 2013

    Y1 - 2013

    N2 - We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin a5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin a5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin a6ß1-mediated interaction of NF B cells with laminin a5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.

    AB - We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin a5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin a5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin a6ß1-mediated interaction of NF B cells with laminin a5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.

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    U2 - 10.1073/pnas.1218131110

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    M3 - Article

    VL - 110

    SP - E2915-E2924

    JO - Proceedings of the National Academy of Sciences

    JF - Proceedings of the National Academy of Sciences

    SN - 0027-8424

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    ER -