TY - JOUR
T1 - Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival
AU - Song, Jian
AU - Lokmic, Zerina
AU - Lämmermann, Tim
AU - Rolf, Julia
AU - Wu, Chuan
AU - Zhang, Xueli
AU - Hallmann, Rupert
AU - Hannocks, Melanie-Jane
AU - Horn, Nathalie
AU - Ruegg, Markus A.
AU - Sonnenberg, Arnoud
AU - Georges-Labouesse, Elisabeth
AU - Winkler, Thomas H.
AU - Kearney, John F.
AU - Cardell, Susanna
AU - Sorokin, Lydia
PY - 2013
Y1 - 2013
N2 - We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin a5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin a5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin a6ß1-mediated interaction of NF B cells with laminin a5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.
AB - We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin a5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin a5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin a6ß1-mediated interaction of NF B cells with laminin a5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.
UR - http://www.scopus.com/inward/record.url?scp=84881103943&partnerID=8YFLogxK
U2 - 10.1073/pnas.1218131110
DO - 10.1073/pnas.1218131110
M3 - Article
C2 - 23847204
AN - SCOPUS:84881103943
SN - 0027-8424
VL - 110
SP - E2915-E2924
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 31
ER -