Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

TY - JOUR

T1 - Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

AU - Song, Jian

AU - Lokmic, Zerina

AU - Lämmermann, Tim

AU - Rolf, Julia

AU - Wu, Chuan

AU - Zhang, Xueli

AU - Hallmann, Rupert

AU - Hannocks, Melanie-Jane

AU - Horn, Nathalie

AU - Ruegg, Markus A.

AU - Sonnenberg, Arnoud

AU - Georges-Labouesse, Elisabeth

AU - Winkler, Thomas H.

AU - Kearney, John F.

AU - Cardell, Susanna

AU - Sorokin, Lydia

PY - 2013

Y1 - 2013

N2 - We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin a5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin a5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin a6ß1-mediated interaction of NF B cells with laminin a5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.

AB - We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin a5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin a5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin a6ß1-mediated interaction of NF B cells with laminin a5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.

UR - https://www.scopus.com/pages/publications/84881103943

U2 - 10.1073/pnas.1218131110

DO - 10.1073/pnas.1218131110

M3 - Article

C2 - 23847204

AN - SCOPUS:84881103943

SN - 0027-8424

VL - 110

SP - E2915-E2924

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 31

ER -