Factors affecting the longevity and strength in an In Vitro model of the bone-ligament interface

Jennifer Z. Paxton, Kenneth Donnelly, Robert P. Keatch, Keith Baar, Liam M. Grover

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    The interfaces between musculoskeletal tissues with contrasting moduli are morphologically and biochemically adapted to allow the transmission of force with minimal injury. Current methods of tissue engineering ligaments and tendons do not include the interface and this may limit the future clinical success of engineered musculoskeletal tissues. This study aimed to use solid brushite cement anchors to engineer intact ligaments from bone-to-bone, creating a functional musculoskeletal interface in vitro. We show here that modifying anchor shape and cement composition can alter both the longevity and the strength of an in vitro model of the bone-ligament interface: with values reaching 23 days and 21.6 kPa, respectively. These results validate the use of brushite bone cement to engineer the bone-ligament interface in vitro and raise the potential for future use in ligament replacement surgery.

    Original languageEnglish
    Pages (from-to)2155-2166
    Number of pages12
    JournalAnnals of Biomedical Engineering
    Volume38
    Issue number6
    DOIs
    Publication statusPublished - Jun 2010

    Keywords

    • Ligament
    • Enthesis
    • Regenerative medicine
    • Brushite
    • CALCIUM-PHOSPHATE CEMENT
    • DONOR-SITE MORBIDITY
    • BRUSHITE CEMENT
    • RECONSTRUCTION
    • HYDROXYAPATITE
    • AUTOGRAFT
    • SCAFFOLD
    • PYROPHOSPHATE
    • INTEGRATION
    • CONSTRUCTS

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