Factors associated with antidepressant, anxiolytic and hypnotic use over 17 years in a national cohort

Ian Colman (Lead / Corresponding author), Tim J. Croudace, Michael E. J. Wadsworth, Peter B. Jones

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Abstract

    Background

    In the general population, most individuals with mental disorders are not treated with psychotropic medications. The objective of this study was to identify factors associated with psychotropic medication use over a 17 year period in a birth cohort.
    Method

    Members of the 1946 British birth cohort (n = 2928 in 1999) reported psychotropic medication use in 1982 at age 36, in 1989 at age 43, and in 1999 at age 53. At each of the three time points, several factors were investigated for their association with antidepressant, anxiolytic or hypnotic medication use.
    Results

    After adjusting for severity of symptoms of depression and anxiety, clinical factors such as suicidal ideation, sleep difficulty and poor physical health were strongly associated with antidepressant, anxiolytic or hypnotic medication use in 1982 and 1989, but not in 1999. Non-clinical factors were infrequently associated with antidepressant, anxiolytic or hypnotic medication use in 1982 and 1989 after adjusting for severity of symptoms, however several non-clinical factors were associated with antidepressant, anxiolytic or hypnotic medication use in 1999 including being female (OR = 1.4, 95% CI: 1.0, 1.9), unemployment (OR = 2.9, 95% CI: 2.1, 4.1), living alone (OR = 2.6, 95% CI: 1.7, 3.9), and being divorced, separated or widowed (OR = 1.5, 95% CI: 1.1, 2.3).
    Limitations

    Data were not available on help-seeking behaviour.
    Conclusions

    Treatment of mental disorder with psychotropic medications is strongly associated with clinical factors. However, non-clinical factors continue to be significant, and may influence both treatment-seeking and prescribing behaviour.
    Original languageEnglish
    Pages (from-to)234-240
    Number of pages7
    JournalJournal of Affective Disorders
    Volume110
    Issue number3
    DOIs
    Publication statusPublished - Oct 2008

    Keywords

    • Psychiatry and Mental health
    • Behavioral Neuroscience
    • Biological Psychiatry
    • Neurology
    • Psychology

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