Projects per year
Abstract
Background: Polypectomy may be performed at colonoscopy and then subsequent surveillance undertaken. It is thought that faecal haemoglobin concentration (f-Hb), estimated by quantitative faecal immunochemical tests (FIT), might be a useful tumour marker.
Methods: Consecutive patients enrolled in colonoscopy surveillance were approached at two hospitals. A specimen for FIT was provided before colonoscopy and, ideally after 3 weeks, a second FIT sample from those who had polypectomy. A single FIT system (OC-Sensor io, Eiken Chemical Co., Ltd) was used to generate f-Hb.
Results: 1103 Patients were invited; 643 returned a FIT device (uptake: 58.3%). Four patients had known inflammatory bowel disease (IBD) and were excluded, leaving 639 (57.9%) with an age range of 25–90 years (median 64 years), 54.6% male. Of 593 patients who had a f-Hb result and completed colonoscopy, advanced neoplasia was found in 41 (6.9%); four colorectal cancer (CRC): 0.7% and 37 advanced adenoma (AA): 6.3%, and a further 127 (21.4%) had non-advanced adenoma (NAA). The median f-Hb was significantly greater in AA as compared to NAA; 6.0 versus 1.0 μg Hb/g faeces, p < 0.0001.134/164 (81.7%) of invited patients returned a second FIT device: 28 were patients with AA in whom median pre-polypectomy f-Hb was 19.2, falling to 3.5 μg Hb/g faeces post-polypectomy, p = 0.01, and 106 with NAA had median pre-polypectomy f-Hb 0.8 compared to 1.0 μg Hb/g faeces post-polypectomy, p = 0.96.
Conclusions: Quantitative FIT could provide a good tumour marker in post-polypectomy surveillance, reduce colonoscopy requirements and minimise potential risk to patients.
Original language | English |
---|---|
Pages (from-to) | 272-276 |
Number of pages | 5 |
Journal | Annals of Clinical Biochemistry |
Volume | 59 |
Issue number | 4 |
Early online date | 2 Mar 2022 |
DOIs | |
Publication status | Published - Jul 2022 |
Keywords
- Adenoma
- colorectal cancer
- faecal immunochemical test
- faecal haemoglobin
- polypectomy
- surveillance
ASJC Scopus subject areas
- Clinical Biochemistry
Fingerprint
Dive into the research topics of 'Faecal haemoglobin concentration in adenoma, before and after polypectomy, approaches the ideal tumour marker'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Can a Negative Faecal Immunochemical Test for Haemoglobin (FIT) Avoid the Need for Routine Surveillance Colonoscopy in Patients at Increased Risk of Colorectal Cancer
Mowat, C. (Investigator), Steele, B. (Investigator) & Strachan, J. (Investigator)
1/04/14 → 31/03/16
Project: Research