Faecal haemoglobin concentration is related to severity of colorectal neoplasia

Jayne Digby; Callum G. Fraser; Francis A. Carey; Paula J. McDonald; Judith A. Strachan; Robert H. Diament; Margaret Balsitis; Robert J. C. Steele

doi:10.1136/jclinpath-2013-201445

Faecal haemoglobin concentration is related to severity of colorectal neoplasia

Jayne Digby, Callum G. Fraser, Francis A. Carey, Paula J. McDonald, Judith A. Strachan, Robert H. Diament, Margaret Balsitis, Robert J. C. Steele

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

Aims Guaiac faecal occult blood tests are being replaced by faecal immunochemical tests (FIT). We investigated whether faecal haemoglobin concentration (f-Hb) was related to stage in progression of colorectal neoplasia, studying cancer and adenoma characteristics in an evaluation of quantitative FIT as a first-line screening test.

Methods We invited 66 225 individuals aged 50-74 years to provide one sample of faeces. f-Hb was measured on samples from 38 720 responders. Colonoscopy findings and pathology data were collected on the 943 with f-Hb >= 400 ng Hb/ml (80 mu g Hb/g faeces).

Results Of the 814 participants with outcome data (median age: 63 years, range 50-75, 56.4% male), 39 had cancer, 190 high-risk adenoma (HRA, defined as >= 3 or any >= 10 mm) and 119 low-risk adenoma (LRA). 74.4% of those with cancer had nf-Hb> 1000 ng Hb/ml compared with 58.4% with HRA, and 44.1% with no pathology. Median f-Hb concentration was higher in those with cancer than those with no (p10 mm) compared with small adenoma (p

Conclusions f-Hb is related to severity of colorectal neoplastic disease. This has ramifications for the selection of the appropriate cut-off concentration adopted for bowel screening programmes.

Original language	English
Pages (from-to)	415-419
Number of pages	5
Journal	Journal of Clinical Pathology
Volume	66
Issue number	5
DOIs	https://doi.org/10.1136/jclinpath-2013-201445
Publication status	Published - 2013

Keywords

3 ROUNDS
PROGRAM
TESTS
OCCULT BLOOD-TEST
CANCER SCREENING PILOT
PERFORMANCE

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/jclinpath-2013-201445

An analysis of the utility of quantitative faecal immunochemical tests in screening and symptomatic populations
McDonald, P. J. (Author), Steele, R. (Supervisor) & Bartlett, W. (Supervisor), 2016
Student thesis: Doctoral Thesis › Doctor of Philosophy

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The relationship between faecal haemoglobin concentration and risk of significant colorectal neoplasia in screening and symptomatic populations.
Digby, J. (Author), Steele, R. (Supervisor) & Fraser, C. (Supervisor), 2016
Student thesis: Doctoral Thesis › Doctor of Philosophy

File

Cite this

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title = "Faecal haemoglobin concentration is related to severity of colorectal neoplasia",

abstract = "Aims Guaiac faecal occult blood tests are being replaced by faecal immunochemical tests (FIT). We investigated whether faecal haemoglobin concentration (f-Hb) was related to stage in progression of colorectal neoplasia, studying cancer and adenoma characteristics in an evaluation of quantitative FIT as a first-line screening test.Methods We invited 66 225 individuals aged 50-74 years to provide one sample of faeces. f-Hb was measured on samples from 38 720 responders. Colonoscopy findings and pathology data were collected on the 943 with f-Hb >= 400 ng Hb/ml (80 mu g Hb/g faeces).Results Of the 814 participants with outcome data (median age: 63 years, range 50-75, 56.4% male), 39 had cancer, 190 high-risk adenoma (HRA, defined as >= 3 or any >= 10 mm) and 119 low-risk adenoma (LRA). 74.4% of those with cancer had nf-Hb> 1000 ng Hb/ml compared with 58.4% with HRA, and 44.1% with no pathology. Median f-Hb concentration was higher in those with cancer than those with no (p10 mm) compared with small adenoma (pConclusions f-Hb is related to severity of colorectal neoplastic disease. This has ramifications for the selection of the appropriate cut-off concentration adopted for bowel screening programmes.",

keywords = "3 ROUNDS, PROGRAM, TESTS, OCCULT BLOOD-TEST, CANCER SCREENING PILOT, PERFORMANCE",

author = "Jayne Digby and Fraser, {Callum G.} and Carey, {Francis A.} and McDonald, {Paula J.} and Strachan, {Judith A.} and Diament, {Robert H.} and Margaret Balsitis and Steele, {Robert J. C.}",

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doi = "10.1136/jclinpath-2013-201445",

language = "English",

volume = "66",

pages = "415--419",

journal = "Journal of Clinical Pathology",

issn = "0021-9746",

publisher = "BMJ Publishing Group",

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T1 - Faecal haemoglobin concentration is related to severity of colorectal neoplasia

AU - Digby, Jayne

AU - Fraser, Callum G.

AU - Carey, Francis A.

AU - McDonald, Paula J.

AU - Strachan, Judith A.

AU - Diament, Robert H.

AU - Balsitis, Margaret

AU - Steele, Robert J. C.

PY - 2013

Y1 - 2013

N2 - Aims Guaiac faecal occult blood tests are being replaced by faecal immunochemical tests (FIT). We investigated whether faecal haemoglobin concentration (f-Hb) was related to stage in progression of colorectal neoplasia, studying cancer and adenoma characteristics in an evaluation of quantitative FIT as a first-line screening test.Methods We invited 66 225 individuals aged 50-74 years to provide one sample of faeces. f-Hb was measured on samples from 38 720 responders. Colonoscopy findings and pathology data were collected on the 943 with f-Hb >= 400 ng Hb/ml (80 mu g Hb/g faeces).Results Of the 814 participants with outcome data (median age: 63 years, range 50-75, 56.4% male), 39 had cancer, 190 high-risk adenoma (HRA, defined as >= 3 or any >= 10 mm) and 119 low-risk adenoma (LRA). 74.4% of those with cancer had nf-Hb> 1000 ng Hb/ml compared with 58.4% with HRA, and 44.1% with no pathology. Median f-Hb concentration was higher in those with cancer than those with no (p10 mm) compared with small adenoma (pConclusions f-Hb is related to severity of colorectal neoplastic disease. This has ramifications for the selection of the appropriate cut-off concentration adopted for bowel screening programmes.

AB - Aims Guaiac faecal occult blood tests are being replaced by faecal immunochemical tests (FIT). We investigated whether faecal haemoglobin concentration (f-Hb) was related to stage in progression of colorectal neoplasia, studying cancer and adenoma characteristics in an evaluation of quantitative FIT as a first-line screening test.Methods We invited 66 225 individuals aged 50-74 years to provide one sample of faeces. f-Hb was measured on samples from 38 720 responders. Colonoscopy findings and pathology data were collected on the 943 with f-Hb >= 400 ng Hb/ml (80 mu g Hb/g faeces).Results Of the 814 participants with outcome data (median age: 63 years, range 50-75, 56.4% male), 39 had cancer, 190 high-risk adenoma (HRA, defined as >= 3 or any >= 10 mm) and 119 low-risk adenoma (LRA). 74.4% of those with cancer had nf-Hb> 1000 ng Hb/ml compared with 58.4% with HRA, and 44.1% with no pathology. Median f-Hb concentration was higher in those with cancer than those with no (p10 mm) compared with small adenoma (pConclusions f-Hb is related to severity of colorectal neoplastic disease. This has ramifications for the selection of the appropriate cut-off concentration adopted for bowel screening programmes.

KW - 3 ROUNDS

KW - PROGRAM

KW - TESTS

KW - OCCULT BLOOD-TEST

KW - CANCER SCREENING PILOT

KW - PERFORMANCE

U2 - 10.1136/jclinpath-2013-201445

DO - 10.1136/jclinpath-2013-201445

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JF - Journal of Clinical Pathology

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Faecal haemoglobin concentration is related to severity of colorectal neoplasia

Abstract

Keywords

UN SDGs

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Student theses

An analysis of the utility of quantitative faecal immunochemical tests in screening and symptomatic populations

The relationship between faecal haemoglobin concentration and risk of significant colorectal neoplasia in screening and symptomatic populations.

Cite this