Faecal Haemoglobin Estimated by Faecal Immunochemical Tests: An Indicator of Systemic Inflammation with Real Clinical Potential

Karen Barnett, Gavin R. C. Clark, Bob Steele, Callum Fraser (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)
33 Downloads (Pure)

Abstract

Multimorbidity is the major cause of ill-health and premature death in developed countries. The ability to identify individuals at risk of developing chronic disease, particularly multimorbidity, reliably, and simply, and to identify undiagnosed disorders, is vital to reducing the global burden of disease. This narrative review, the first of recent studies, demonstrates that raised faecal haemoglobin concentration (f-Hb) is associated with increased all-cause and cause-specific mortality and with longer-term conditions including diabetes, hypertension, cardiovascular disease, and psoriasis, and with probable intake of particulate matter. We and others have hypothesized that elevated f-Hb (measured using a faecal immunochemical test) has considerable potential to identify individuals at risk of, or who already have, early stage, undiagnosed chronic disease. If f-Hb does prove to be an effective biomarker for chronic disease and multimorbidity, individuals with detectable f-Hb, but without an obvious source of gastrointestinal blood loss, could benefit from further assessment and early intervention. To test this hypothesis rigorously, longitudinal data-linkage methodology is required linking colorectal cancer screening data, and data on patients presenting with lower gastrointestinal symptoms, with routinely collected health information.
Original languageEnglish
Article number2093
Number of pages9
JournalDiagnostics
Volume11
Issue number11
DOIs
Publication statusPublished - 12 Nov 2021

Keywords

  • chronic disease
  • data linkage
  • faecal haemoglobin
  • faecal immunochemical test
  • inflammation
  • multimorbidity
  • screening

Fingerprint

Dive into the research topics of 'Faecal Haemoglobin Estimated by Faecal Immunochemical Tests: An Indicator of Systemic Inflammation with Real Clinical Potential'. Together they form a unique fingerprint.

Cite this