Failure of elimination of paternal mitochondrial DNA in abnormal embryos

J St John, D Sakkas, K Dimitriadi, A Barnes, V Maclin, J Ramey, C Barratt, C De Jonge

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Paternal mitochondrial DNA is normally eliminated from mammalian embryos. We have shown the presence of paternal mtDNA at the blastocyst stage in some abnormal human embryos.

Original languageEnglish
Pages (from-to)200
JournalLancet
Volume355
Issue number9199
DOIs
Publication statusPublished - 15 Jan 2000

Keywords

  • Blastocyst
  • DNA, Mitochondrial/genetics
  • Embryo, Mammalian
  • Fathers
  • Female
  • Fertilization in Vitro
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Pregnancy
  • Sperm Injections, Intracytoplasmic

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  • Cite this

    St John, J., Sakkas, D., Dimitriadi, K., Barnes, A., Maclin, V., Ramey, J., Barratt, C., & De Jonge, C. (2000). Failure of elimination of paternal mitochondrial DNA in abnormal embryos. Lancet, 355(9199), 200. https://doi.org/10.1016/S0140-6736(99)03842-8