Failure of elimination of paternal mitochondrial DNA in abnormal embryos

J St John; D Sakkas; K Dimitriadi; A Barnes; V Maclin; J Ramey; C Barratt; C De Jonge

doi:10.1016/S0140-6736(99)03842-8

Failure of elimination of paternal mitochondrial DNA in abnormal embryos

J St John
, D Sakkas
, K Dimitriadi
, A Barnes
, V Maclin
, J Ramey
, C Barratt
, C De Jonge

Undergraduate Medicine

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

Paternal mitochondrial DNA is normally eliminated from mammalian embryos. We have shown the presence of paternal mtDNA at the blastocyst stage in some abnormal human embryos.

Original language	English
Pages (from-to)	200
Journal	Lancet
Volume	355
Issue number	9199
DOIs	https://doi.org/10.1016/S0140-6736(99)03842-8
Publication status	Published - 15 Jan 2000

Keywords

Blastocyst
DNA, Mitochondrial/genetics
Embryo, Mammalian
Fathers
Female
Fertilization in Vitro
Humans
Male
Polymerase Chain Reaction
Pregnancy
Sperm Injections, Intracytoplasmic

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10.1016/S0140-6736(99)03842-8

Cite this

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title = "Failure of elimination of paternal mitochondrial DNA in abnormal embryos",

abstract = "Paternal mitochondrial DNA is normally eliminated from mammalian embryos. We have shown the presence of paternal mtDNA at the blastocyst stage in some abnormal human embryos.",

keywords = "Blastocyst, DNA, Mitochondrial/genetics, Embryo, Mammalian, Fathers, Female, Fertilization in Vitro, Humans, Male, Polymerase Chain Reaction, Pregnancy, Sperm Injections, Intracytoplasmic",

author = "\{St John\}, J and D Sakkas and K Dimitriadi and A Barnes and V Maclin and J Ramey and C Barratt and \{De Jonge\}, C",

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T1 - Failure of elimination of paternal mitochondrial DNA in abnormal embryos

AU - St John, J

AU - Sakkas, D

AU - Dimitriadi, K

AU - Barnes, A

AU - Maclin, V

AU - Ramey, J

AU - Barratt, C

AU - De Jonge, C

PY - 2000/1/15

Y1 - 2000/1/15

N2 - Paternal mitochondrial DNA is normally eliminated from mammalian embryos. We have shown the presence of paternal mtDNA at the blastocyst stage in some abnormal human embryos.

AB - Paternal mitochondrial DNA is normally eliminated from mammalian embryos. We have shown the presence of paternal mtDNA at the blastocyst stage in some abnormal human embryos.

KW - Blastocyst

KW - DNA, Mitochondrial/genetics

KW - Embryo, Mammalian

KW - Fathers

KW - Female

KW - Fertilization in Vitro

KW - Humans

KW - Male

KW - Polymerase Chain Reaction

KW - Pregnancy

KW - Sperm Injections, Intracytoplasmic

U2 - 10.1016/S0140-6736(99)03842-8

DO - 10.1016/S0140-6736(99)03842-8

M3 - Article

C2 - 10675122

SN - 0140-6736

VL - 355

SP - 200

JO - Lancet

JF - Lancet

IS - 9199

ER -

Failure of elimination of paternal mitochondrial DNA in abnormal embryos

Abstract

Keywords

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