FANCJ: solving problems in DNA replication

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    Abstract

    The FANCJ protein (also known as BACH1 and BRIP1) is a DNA helicase that is required to preserve the genetic and structural integrity of the genome in complex eukaryotes. In humans, mutations in FANCJ are associated with the chromosome instability disorder Fanconi's anemia and also with the inherited predisposition early-onset breast cancer. Here I will discuss the contribution of FANCJ to human disease, its role in maintenance of genome stability and some current thoughts on the mechanisms through which this is achieved. (C) 2010 Elsevier B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)250-256
    Number of pages7
    JournalDNA Repair
    Volume9
    Issue number3
    DOIs
    Publication statusPublished - 2 Mar 2010

    Keywords

    • Fanconi anemia
    • Helicase
    • FANCJ
    • DNA repair
    • DNA replication
    • HELICASE-LIKE PROTEIN
    • IRON-SULFUR CLUSTER
    • CROSS-LINK REPAIR
    • G-QUADRUPLEX DNA
    • HOMOLOGOUS RECOMBINATION
    • CAENORHABDITIS-ELEGANS
    • BREAST-CANCER
    • G4 DNA
    • SUBSTRATE-SPECIFICITY
    • GENOMIC STABILITY

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