Fats and function: protein lipid modifications in plant cell signalling

Dionne Turnbull, Piers A. Hemsley (Lead / Corresponding author)

Research output: Contribution to journalReview article

8 Citations (Scopus)
168 Downloads (Pure)

Abstract

The post-translational lipid modifications N-myristoylation, prenylation and S-acylation are traditionally associated with increasing protein membrane affinity. However this is an over-simplification, with evidence now implicating these modifications in a variety of roles such as membrane microdomain partitioning, protein trafficking, protein complex assembly and polarity maintenance. Evidence for a regulatory role is also emerging, with changes or manipulation of lipid modifications offering a means of directly controlling various aspects of protein function. Proteomics advances have revealed an enrichment of signalling proteins in the lipid-modified proteome, potentially indicating an important role for these modifications in responding to stimuli. This review highlights some of the key themes and possible functions of lipid modification during signalling processes in plants.
Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalCurrent Opinion in Plant Biology
Volume40
Early online date31 Jul 2017
DOIs
Publication statusPublished - Dec 2017

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