Feasibility of a trial to evaluate nicotinamide for chemoprevention of skin cancers in organ transplant recipients in the UK

C. E. Gollins (Lead / Corresponding author), A. Shah, K. Sinha, S. Khan, N. Paul, B. Meeajun, R. A. Abbott, C. Blasdale, H. Cooper, C. A. Harwood, F. Ismail, J. T. Lear, L. Mackintosh, S. McCormack, C. M. Perrett, C. M. Proby, A. Durack, R. Patalay, R. N. Matin

Research output: Contribution to journalLetter

Abstract

Keratinocyte cancers (KC) are the commonest malignancies in the UK population, with rates increasing annually. Nicotinamide (vitamin B3) has recently been reported to reduce the incidence of KC in high-risk patients. It is a precursor of nicotinamide adenine dinucleotide (NAD+) which replenishes cellular energy levels and enhances efficient repair of ultraviolet light (UV) induced DNA damage within keratinocytes.

Original languageEnglish
Number of pages4
JournalBritish Journal of Dermatology
Early online date2 Mar 2020
DOIs
Publication statusPublished - 7 Apr 2020

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    Gollins, C. E., Shah, A., Sinha, K., Khan, S., Paul, N., Meeajun, B., Abbott, R. A., Blasdale, C., Cooper, H., Harwood, C. A., Ismail, F., Lear, J. T., Mackintosh, L., McCormack, S., Perrett, C. M., Proby, C. M., Durack, A., Patalay, R., & Matin, R. N. (2020). Feasibility of a trial to evaluate nicotinamide for chemoprevention of skin cancers in organ transplant recipients in the UK. British Journal of Dermatology. https://doi.org/10.1111/bjd.18982