Feasibility study to assess the impact of a lifestyle intervention (‘LivingWELL’) in people having an assessment of their family history of colorectal or breast cancer

Annie S. Anderson; Jacqueline Dunlop; Stephanie Gallant; Maureen Macleod; Zosia Miedzybrodska; Nanette Mutrie; Ronan E. O’Carroll; Martine Stead; Robert J. C. Steele; Rod S. Taylor; Sarah Vinnicombe; Jonathan Berg

doi:10.1136/ bmjopen-2017-019410

Feasibility study to assess the impact of a lifestyle intervention (‘LivingWELL’) in people having an assessment of their family history of colorectal or breast cancer

Annie S. Anderson (Lead / Corresponding author)
, Jacqueline Dunlop
, Stephanie Gallant
, Maureen Macleod
, Zosia Miedzybrodska
, Nanette Mutrie
, Ronan E. O’Carroll
, Martine Stead
, Robert J. C. Steele
, Rod S. Taylor
, Sarah Vinnicombe
, Jonathan Berg

Undergraduate Medicine

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

211 Downloads (Pure)

Abstract

Objectives: To assess the feasibility of delivering and evaluating a weight management (WM) programme for overweight patients with a family history (FH) of breast (BC) or colorectal (CRC) cancer.

Study Design: A two arm (intervention versus usual care) RCT

Setting: NHS Tayside and NHS Grampian

Participants: People with a FH of BC or CRC aged >18 years and Body Mass Index >25kg/m2 referred to NHS genetic services

Intervention: Participants were randomised to a control (lifestyle booklet) or 12 week intervention arm where they were given one face to face counselling session, 4 telephone consultations and web based support. A goal of 5% reduction in body weight was set and a personalised diet and physical activity (PA) programme provided. Behavioural change techniques (motivational interviewing, action and coping plans and implementation intentions) were utilised.

Primary outcome: Feasibility measures – recruitment, programme implementation, fidelity measures, achieved measurements and retention, participant satisfaction assessed by questionnaire and qualitative interviews.

Secondary outcomes: Measured changes in weight and PA and reported diet and psycho-social measures between baseline and 12 week follow-up.

Results: Of 480 patients approached, 196 (41%) expressed interest in the study and of those 78 (40%) were randomised. Implementation of the programme was challenging within the time allotted and fidelity to the intervention modest (62%). Qualitative findings indicated the programme was well received. Questionnaires and anthropometric data were completed by >98%. Accelerometer data was attained by 84% and 54% at baseline and follow up respectively. Retention at 12 weeks was 76%. Overall, 36% of the intervention group (vs 0% in control) achieved 5% weight loss. Favourable increases in PA and reduction in dietary fat were also reported.

Conclusions: A lifestyle programme for people with a family history of cancer is feasible to conduct, acceptable to participants and indicative results suggest favourable outcomes.

Original language	English
Article number	e019410
Number of pages	11
Journal	BMJ Open
Volume	8
Issue number	2
Early online date	1 Feb 2018
DOIs	https://doi.org/10.1136/ bmjopen-2017-019410
Publication status	Published - Feb 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer genetics
Nutritional support
Preventive medicine
Public health

ASJC Scopus subject areas

General Medicine

Access to Document

10.1136/ bmjopen-2017-019410Licence: CC BY-NC

Final Published Version
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Final published version, 1.23 MBLicence: CC BY-NC

LivingWell - A Feasibility Study to Assess the Impact of a Lifestyle Intervention in People Attending Family History Clinics with an Increased Risk of Colorectal or Breast Cancer (Joint with University of Stirling, University of Aberdeen, University of Edinburgh, University of Exeter, NHS Grampian and NHS Tayside)
Anderson, A. (Investigator), Berg, J. (Investigator), Dunlop, J. (Investigator), Steele, B. (Investigator) & Vinnicombe, S. (Investigator)
Chief Scientist Office
1/05/15 → 1/01/17
Project: Research

Cite this

Anderson, A. S., Dunlop, J., Gallant, S., Macleod, M., Miedzybrodska, Z., Mutrie, N., O’Carroll, R. E., Stead, M., Steele, R. J. C., Taylor, R. S., Vinnicombe, S., & Berg, J. (2018). Feasibility study to assess the impact of a lifestyle intervention (‘LivingWELL’) in people having an assessment of their family history of colorectal or breast cancer. BMJ Open, 8(2), Article e019410. https://doi.org/10.1136/ bmjopen-2017-019410

@article{85e59159dfd443579693b466b32a3cdf,

title = "Feasibility study to assess the impact of a lifestyle intervention ({\textquoteleft}LivingWELL{\textquoteright}) in people having an assessment of their family history of colorectal or breast cancer",

abstract = "Objectives: To assess the feasibility of delivering and evaluating a weight management (WM) programme for overweight patients with a family history (FH) of breast (BC) or colorectal (CRC) cancer. Study Design: A two arm (intervention versus usual care) RCT Setting: NHS Tayside and NHS Grampian Participants: People with a FH of BC or CRC aged >18 years and Body Mass Index >25kg/m2 referred to NHS genetic services Intervention: Participants were randomised to a control (lifestyle booklet) or 12 week intervention arm where they were given one face to face counselling session, 4 telephone consultations and web based support. A goal of 5\% reduction in body weight was set and a personalised diet and physical activity (PA) programme provided. Behavioural change techniques (motivational interviewing, action and coping plans and implementation intentions) were utilised. Primary outcome: Feasibility measures – recruitment, programme implementation, fidelity measures, achieved measurements and retention, participant satisfaction assessed by questionnaire and qualitative interviews. Secondary outcomes: Measured changes in weight and PA and reported diet and psycho-social measures between baseline and 12 week follow-up. Results: Of 480 patients approached, 196 (41\%) expressed interest in the study and of those 78 (40\%) were randomised. Implementation of the programme was challenging within the time allotted and fidelity to the intervention modest (62\%). Qualitative findings indicated the programme was well received. Questionnaires and anthropometric data were completed by >98\%. Accelerometer data was attained by 84\% and 54\% at baseline and follow up respectively. Retention at 12 weeks was 76\%. Overall, 36\% of the intervention group (vs 0\% in control) achieved 5\% weight loss. Favourable increases in PA and reduction in dietary fat were also reported. Conclusions: A lifestyle programme for people with a family history of cancer is feasible to conduct, acceptable to participants and indicative results suggest favourable outcomes.",

keywords = "Cancer genetics, Nutritional support, Preventive medicine, Public health",

author = "Anderson, \{Annie S.\} and Jacqueline Dunlop and Stephanie Gallant and Maureen Macleod and Zosia Miedzybrodska and Nanette Mutrie and O{\textquoteright}Carroll, \{Ronan E.\} and Martine Stead and Steele, \{Robert J. C.\} and Taylor, \{Rod S.\} and Sarah Vinnicombe and Jonathan Berg",

note = "This work was supported by Chief Scientist Office for Scotland, grant number CZH/4/1080.",

year = "2018",

month = feb,

doi = "10.1136/ bmjopen-2017-019410",

language = "English",

volume = "8",

journal = "BMJ Open",

issn = "2044-6055",

publisher = "BMJ Publishing Group",

number = "2",

}

Anderson, AS, Dunlop, J, Gallant, S, Macleod, M, Miedzybrodska, Z, Mutrie, N, O’Carroll, RE, Stead, M, Steele, RJC, Taylor, RS, Vinnicombe, S & Berg, J 2018, 'Feasibility study to assess the impact of a lifestyle intervention (‘LivingWELL’) in people having an assessment of their family history of colorectal or breast cancer', BMJ Open, vol. 8, no. 2, e019410. https://doi.org/10.1136/ bmjopen-2017-019410

Feasibility study to assess the impact of a lifestyle intervention (‘LivingWELL’) in people having an assessment of their family history of colorectal or breast cancer. / Anderson, Annie S. (Lead / Corresponding author); Dunlop, Jacqueline; Gallant, Stephanie et al.
In: BMJ Open, Vol. 8, No. 2, e019410, 02.2018.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Feasibility study to assess the impact of a lifestyle intervention (‘LivingWELL’) in people having an assessment of their family history of colorectal or breast cancer

AU - Anderson, Annie S.

AU - Dunlop, Jacqueline

AU - Gallant, Stephanie

AU - Macleod, Maureen

AU - Miedzybrodska, Zosia

AU - Mutrie, Nanette

AU - O’Carroll, Ronan E.

AU - Stead, Martine

AU - Steele, Robert J. C.

AU - Taylor, Rod S.

AU - Vinnicombe, Sarah

AU - Berg, Jonathan

N1 - This work was supported by Chief Scientist Office for Scotland, grant number CZH/4/1080.

PY - 2018/2

Y1 - 2018/2

N2 - Objectives: To assess the feasibility of delivering and evaluating a weight management (WM) programme for overweight patients with a family history (FH) of breast (BC) or colorectal (CRC) cancer. Study Design: A two arm (intervention versus usual care) RCT Setting: NHS Tayside and NHS Grampian Participants: People with a FH of BC or CRC aged >18 years and Body Mass Index >25kg/m2 referred to NHS genetic services Intervention: Participants were randomised to a control (lifestyle booklet) or 12 week intervention arm where they were given one face to face counselling session, 4 telephone consultations and web based support. A goal of 5% reduction in body weight was set and a personalised diet and physical activity (PA) programme provided. Behavioural change techniques (motivational interviewing, action and coping plans and implementation intentions) were utilised. Primary outcome: Feasibility measures – recruitment, programme implementation, fidelity measures, achieved measurements and retention, participant satisfaction assessed by questionnaire and qualitative interviews. Secondary outcomes: Measured changes in weight and PA and reported diet and psycho-social measures between baseline and 12 week follow-up. Results: Of 480 patients approached, 196 (41%) expressed interest in the study and of those 78 (40%) were randomised. Implementation of the programme was challenging within the time allotted and fidelity to the intervention modest (62%). Qualitative findings indicated the programme was well received. Questionnaires and anthropometric data were completed by >98%. Accelerometer data was attained by 84% and 54% at baseline and follow up respectively. Retention at 12 weeks was 76%. Overall, 36% of the intervention group (vs 0% in control) achieved 5% weight loss. Favourable increases in PA and reduction in dietary fat were also reported. Conclusions: A lifestyle programme for people with a family history of cancer is feasible to conduct, acceptable to participants and indicative results suggest favourable outcomes.

AB - Objectives: To assess the feasibility of delivering and evaluating a weight management (WM) programme for overweight patients with a family history (FH) of breast (BC) or colorectal (CRC) cancer. Study Design: A two arm (intervention versus usual care) RCT Setting: NHS Tayside and NHS Grampian Participants: People with a FH of BC or CRC aged >18 years and Body Mass Index >25kg/m2 referred to NHS genetic services Intervention: Participants were randomised to a control (lifestyle booklet) or 12 week intervention arm where they were given one face to face counselling session, 4 telephone consultations and web based support. A goal of 5% reduction in body weight was set and a personalised diet and physical activity (PA) programme provided. Behavioural change techniques (motivational interviewing, action and coping plans and implementation intentions) were utilised. Primary outcome: Feasibility measures – recruitment, programme implementation, fidelity measures, achieved measurements and retention, participant satisfaction assessed by questionnaire and qualitative interviews. Secondary outcomes: Measured changes in weight and PA and reported diet and psycho-social measures between baseline and 12 week follow-up. Results: Of 480 patients approached, 196 (41%) expressed interest in the study and of those 78 (40%) were randomised. Implementation of the programme was challenging within the time allotted and fidelity to the intervention modest (62%). Qualitative findings indicated the programme was well received. Questionnaires and anthropometric data were completed by >98%. Accelerometer data was attained by 84% and 54% at baseline and follow up respectively. Retention at 12 weeks was 76%. Overall, 36% of the intervention group (vs 0% in control) achieved 5% weight loss. Favourable increases in PA and reduction in dietary fat were also reported. Conclusions: A lifestyle programme for people with a family history of cancer is feasible to conduct, acceptable to participants and indicative results suggest favourable outcomes.

KW - Cancer genetics

KW - Nutritional support

KW - Preventive medicine

KW - Public health

U2 - 10.1136/ bmjopen-2017-019410

DO - 10.1136/ bmjopen-2017-019410

M3 - Article

SN - 2044-6055

VL - 8

JO - BMJ Open

JF - BMJ Open

IS - 2

M1 - e019410

ER -

Feasibility study to assess the impact of a lifestyle intervention (‘LivingWELL’) in people having an assessment of their family history of colorectal or breast cancer

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Projects

Cite this