FEM Analysis of Carbon Nanotube Induced Cell Poration Under Electric Field

Dun Liu; Zhigang Wang; Lijun Wang; Alfred Cuschieri

doi:10.1109/BMEI.2010.5639585

FEM Analysis of Carbon Nanotube Induced Cell Poration Under Electric Field

Dun Liu, Zhigang Wang, Lijun Wang, Alfred Cuschieri

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Citations (Scopus)

Abstract

Carbon nanotubes (CNTs) are promising nanomaterials for biomedical applications in view of their excellent mechanical, chemical and electrical properties. Recently, CNTs have been used as electroporation agents because they are able to reduce significantly the required electroporation field. However, mechanism of CNT mediated electroporation enhancement is not fully understood. In this finite element method (FEM) modeling study, an electrokinetic-induced force and mechanical motion of a CNT and CNT-cell membrane in a fluid domain under an applied electric field were investigated. Based on dielectrophoresis (DEP) theory, force induced on the CNT tip was calculated, and then cell membrane displacement under this force was simulated. Our results suggest that dielectrophoretic force induced on the tip of carbon nanotubes is able to achieve rapid cell membrane deformation, which may explain the observed enhancement of cell electroporation.

Original language	English
Title of host publication	2010 3RD INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS (BMEI 2010), VOLS 1-7
Editors	W Yu, M Zhang, L Wang, Y Song
Place of Publication	NEW YORK
Publisher	IEEE Computer Society
Pages	1189-1193
Number of pages	5
Volume	3
ISBN (Print)	978-1-4244-6496-8
DOIs	https://doi.org/10.1109/BMEI.2010.5639585
Publication status	Published - 2010
Event	3rd International Conference on Biomedical Engineering and Informatics - Yantai, China Duration: 16 Oct 2010 → 18 Oct 2010 http://www.ieee.org/conferences_events/conferences/conferencedetails/index.html?Conf_ID=16828

Conference

Conference	3rd International Conference on Biomedical Engineering and Informatics
Abbreviated title	BMEI 2010
Country/Territory	China
City	Yantai
Period	16/10/10 → 18/10/10
Internet address	http://www.ieee.org/conferences_events/conferences/conferencedetails/index.html?Conf_ID=16828

Keywords

carbon nanotube
dielectrophoresis
electroporation
membrane deformation
DIELECTROPHORESIS
MEMBRANES
STRESS

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10.1109/BMEI.2010.5639585

Cite this

@inproceedings{ee28177fec1b4d28959760620de7657b,

title = "FEM Analysis of Carbon Nanotube Induced Cell Poration Under Electric Field",

abstract = "Carbon nanotubes (CNTs) are promising nanomaterials for biomedical applications in view of their excellent mechanical, chemical and electrical properties. Recently, CNTs have been used as electroporation agents because they are able to reduce significantly the required electroporation field. However, mechanism of CNT mediated electroporation enhancement is not fully understood. In this finite element method (FEM) modeling study, an electrokinetic-induced force and mechanical motion of a CNT and CNT-cell membrane in a fluid domain under an applied electric field were investigated. Based on dielectrophoresis (DEP) theory, force induced on the CNT tip was calculated, and then cell membrane displacement under this force was simulated. Our results suggest that dielectrophoretic force induced on the tip of carbon nanotubes is able to achieve rapid cell membrane deformation, which may explain the observed enhancement of cell electroporation.",

keywords = "carbon nanotube, dielectrophoresis, electroporation, membrane deformation, DIELECTROPHORESIS, MEMBRANES, STRESS",

author = "Dun Liu and Zhigang Wang and Lijun Wang and Alfred Cuschieri",

year = "2010",

doi = "10.1109/BMEI.2010.5639585",

language = "English",

isbn = "978-1-4244-6496-8",

volume = "3",

pages = "1189--1193",

editor = "W Yu and M Zhang and L Wang and Y Song",

booktitle = "2010 3RD INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS (BMEI 2010), VOLS 1-7",

publisher = "IEEE Computer Society",

note = "3rd International Conference on Biomedical Engineering and Informatics, BMEI 2010 ; Conference date: 16-10-2010 Through 18-10-2010",

url = "http://www.ieee.org/conferences_events/conferences/conferencedetails/index.html?Conf_ID=16828",

}

Liu, D, Wang, Z, Wang, L & Cuschieri, A 2010, FEM Analysis of Carbon Nanotube Induced Cell Poration Under Electric Field. in W Yu, M Zhang, L Wang & Y Song (eds), 2010 3RD INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS (BMEI 2010), VOLS 1-7. vol. 3, IEEE Computer Society, NEW YORK, pp. 1189-1193, 3rd International Conference on Biomedical Engineering and Informatics, Yantai, China, 16/10/10. https://doi.org/10.1109/BMEI.2010.5639585

FEM Analysis of Carbon Nanotube Induced Cell Poration Under Electric Field. / Liu, Dun; Wang, Zhigang; Wang, Lijun et al.
2010 3RD INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS (BMEI 2010), VOLS 1-7. ed. / W Yu; M Zhang; L Wang; Y Song. Vol. 3 NEW YORK: IEEE Computer Society, 2010. p. 1189-1193.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - FEM Analysis of Carbon Nanotube Induced Cell Poration Under Electric Field

AU - Liu, Dun

AU - Wang, Zhigang

AU - Wang, Lijun

AU - Cuschieri, Alfred

PY - 2010

Y1 - 2010

N2 - Carbon nanotubes (CNTs) are promising nanomaterials for biomedical applications in view of their excellent mechanical, chemical and electrical properties. Recently, CNTs have been used as electroporation agents because they are able to reduce significantly the required electroporation field. However, mechanism of CNT mediated electroporation enhancement is not fully understood. In this finite element method (FEM) modeling study, an electrokinetic-induced force and mechanical motion of a CNT and CNT-cell membrane in a fluid domain under an applied electric field were investigated. Based on dielectrophoresis (DEP) theory, force induced on the CNT tip was calculated, and then cell membrane displacement under this force was simulated. Our results suggest that dielectrophoretic force induced on the tip of carbon nanotubes is able to achieve rapid cell membrane deformation, which may explain the observed enhancement of cell electroporation.

AB - Carbon nanotubes (CNTs) are promising nanomaterials for biomedical applications in view of their excellent mechanical, chemical and electrical properties. Recently, CNTs have been used as electroporation agents because they are able to reduce significantly the required electroporation field. However, mechanism of CNT mediated electroporation enhancement is not fully understood. In this finite element method (FEM) modeling study, an electrokinetic-induced force and mechanical motion of a CNT and CNT-cell membrane in a fluid domain under an applied electric field were investigated. Based on dielectrophoresis (DEP) theory, force induced on the CNT tip was calculated, and then cell membrane displacement under this force was simulated. Our results suggest that dielectrophoretic force induced on the tip of carbon nanotubes is able to achieve rapid cell membrane deformation, which may explain the observed enhancement of cell electroporation.

KW - carbon nanotube

KW - dielectrophoresis

KW - electroporation

KW - membrane deformation

KW - DIELECTROPHORESIS

KW - MEMBRANES

KW - STRESS

U2 - 10.1109/BMEI.2010.5639585

DO - 10.1109/BMEI.2010.5639585

M3 - Conference contribution

SN - 978-1-4244-6496-8

VL - 3

SP - 1189

EP - 1193

BT - 2010 3RD INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS (BMEI 2010), VOLS 1-7

A2 - Yu, W

A2 - Zhang, M

A2 - Wang, L

A2 - Song, Y

PB - IEEE Computer Society

CY - NEW YORK

T2 - 3rd International Conference on Biomedical Engineering and Informatics

Y2 - 16 October 2010 through 18 October 2010

ER -

FEM Analysis of Carbon Nanotube Induced Cell Poration Under Electric Field

Abstract

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Keywords

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