FEM Analysis of Carbon Nanotube Induced Cell Poration Under Electric Field

Dun Liu, Zhigang Wang, Lijun Wang, Alfred Cuschieri

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    3 Citations (Scopus)

    Abstract

    Carbon nanotubes (CNTs) are promising nanomaterials for biomedical applications in view of their excellent mechanical, chemical and electrical properties. Recently, CNTs have been used as electroporation agents because they are able to reduce significantly the required electroporation field. However, mechanism of CNT mediated electroporation enhancement is not fully understood. In this finite element method (FEM) modeling study, an electrokinetic-induced force and mechanical motion of a CNT and CNT-cell membrane in a fluid domain under an applied electric field were investigated. Based on dielectrophoresis (DEP) theory, force induced on the CNT tip was calculated, and then cell membrane displacement under this force was simulated. Our results suggest that dielectrophoretic force induced on the tip of carbon nanotubes is able to achieve rapid cell membrane deformation, which may explain the observed enhancement of cell electroporation.

    Original languageEnglish
    Title of host publication2010 3RD INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS (BMEI 2010), VOLS 1-7
    EditorsW Yu, M Zhang, L Wang, Y Song
    Place of PublicationNEW YORK
    PublisherIEEE Computer Society
    Pages1189-1193
    Number of pages5
    Volume3
    ISBN (Print)978-1-4244-6496-8
    DOIs
    Publication statusPublished - 2010
    Event3rd International Conference on Biomedical Engineering and Informatics - Yantai, China
    Duration: 16 Oct 201018 Oct 2010
    http://www.ieee.org/conferences_events/conferences/conferencedetails/index.html?Conf_ID=16828

    Conference

    Conference3rd International Conference on Biomedical Engineering and Informatics
    Abbreviated titleBMEI 2010
    CountryChina
    CityYantai
    Period16/10/1018/10/10
    Internet address

    Keywords

    • carbon nanotube
    • dielectrophoresis
    • electroporation
    • membrane deformation
    • DIELECTROPHORESIS
    • MEMBRANES
    • STRESS

    Cite this

    Liu, D., Wang, Z., Wang, L., & Cuschieri, A. (2010). FEM Analysis of Carbon Nanotube Induced Cell Poration Under Electric Field. In W. Yu, M. Zhang, L. Wang, & Y. Song (Eds.), 2010 3RD INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS (BMEI 2010), VOLS 1-7 (Vol. 3, pp. 1189-1193). IEEE Computer Society. https://doi.org/10.1109/BMEI.2010.5639585