Female age, the length of involuntary infertility prior to investigation and fertility outcome

B. C. Dunphy (Lead / Corresponding author), Richard Kay, C. L. R. Barratt, I. D. Cooke

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The objectives of this study were two-fold: firstly to determine whether female age exerts an influence on the fertility outcome of couples attending an infertility clinic, independent of demographic and clinical details; and secondly to examine the relationship between the length of involuntary infertility prior to investigation and the subsequent chance of conception. Seven-hundred-and-thirty-one subjects whose partner did not have azoospermia were recruited to the study. Female age ranged from 20 to 46 (mean = 31.1). The range of involuntary infertility prior to investigation was 12-216 (mean = 62) months. One-hundred-and-twenty-four women conceived. The following variables achieved the 5% level of significance when a stepwise analysis was performed on all cases; the concentration of spermatozoa exhibiting slow or sluggish linear or non-linear motility (chi 2(1) = 17.57, P less than 0.0001, RR = 1.67 per 50 x 10(6)), female age (chi 2(1) = 12.44, P = 0.0004, RR = 0.92 per annum), tubal status (chi 2(1) = 12.22, P = 0.0005, RR = 2.15), length of infertility before investigation (chi 2(1) = 11.22, P = 0.0008, RR = 0.87 per annum) and past paternity (chi 2(1) = 8.43, P = 0.0037, RR = 1.81). Female age was found to be positively correlated with the incidence and severity of ovulatory dysfunction, tubal occlusive disease, pelvic adhesions and endometriosis. Where the female partner was 'normal' on investigation, all conceptions were independent of treatment to either partner.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish
Pages (from-to)527-530
Number of pages4
JournalHuman Reproduction
Volume4
Issue number5
DOIs
Publication statusPublished - 1 Jul 1989

Fingerprint

Infertility
Fertility
Azoospermia
Paternity
Endometriosis
Spermatozoa
Demography
Incidence
Therapeutics

Keywords

  • Actuarial Analysis
  • Adult
  • Age Factors
  • Aged
  • Endometriosis/complications
  • Fallopian Tubes/abnormalities
  • Female
  • Humans
  • Infertility, Female/etiology
  • Infertility, Male
  • Male
  • Middle Aged
  • Ovulation
  • Pelvic Neoplasms/complications
  • Pelvis/abnormalities
  • Sperm Motility
  • Time Factors
  • Tissue Adhesions

Cite this

Dunphy, B. C. ; Kay, Richard ; Barratt, C. L. R. ; Cooke, I. D. / Female age, the length of involuntary infertility prior to investigation and fertility outcome. In: Human Reproduction. 1989 ; Vol. 4, No. 5. pp. 527-530.
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Female age, the length of involuntary infertility prior to investigation and fertility outcome. / Dunphy, B. C. (Lead / Corresponding author); Kay, Richard; Barratt, C. L. R.; Cooke, I. D.

In: Human Reproduction, Vol. 4, No. 5, 01.07.1989, p. 527-530.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Female age, the length of involuntary infertility prior to investigation and fertility outcome

AU - Dunphy, B. C.

AU - Kay, Richard

AU - Barratt, C. L. R.

AU - Cooke, I. D.

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N2 - The objectives of this study were two-fold: firstly to determine whether female age exerts an influence on the fertility outcome of couples attending an infertility clinic, independent of demographic and clinical details; and secondly to examine the relationship between the length of involuntary infertility prior to investigation and the subsequent chance of conception. Seven-hundred-and-thirty-one subjects whose partner did not have azoospermia were recruited to the study. Female age ranged from 20 to 46 (mean = 31.1). The range of involuntary infertility prior to investigation was 12-216 (mean = 62) months. One-hundred-and-twenty-four women conceived. The following variables achieved the 5% level of significance when a stepwise analysis was performed on all cases; the concentration of spermatozoa exhibiting slow or sluggish linear or non-linear motility (chi 2(1) = 17.57, P less than 0.0001, RR = 1.67 per 50 x 10(6)), female age (chi 2(1) = 12.44, P = 0.0004, RR = 0.92 per annum), tubal status (chi 2(1) = 12.22, P = 0.0005, RR = 2.15), length of infertility before investigation (chi 2(1) = 11.22, P = 0.0008, RR = 0.87 per annum) and past paternity (chi 2(1) = 8.43, P = 0.0037, RR = 1.81). Female age was found to be positively correlated with the incidence and severity of ovulatory dysfunction, tubal occlusive disease, pelvic adhesions and endometriosis. Where the female partner was 'normal' on investigation, all conceptions were independent of treatment to either partner.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - The objectives of this study were two-fold: firstly to determine whether female age exerts an influence on the fertility outcome of couples attending an infertility clinic, independent of demographic and clinical details; and secondly to examine the relationship between the length of involuntary infertility prior to investigation and the subsequent chance of conception. Seven-hundred-and-thirty-one subjects whose partner did not have azoospermia were recruited to the study. Female age ranged from 20 to 46 (mean = 31.1). The range of involuntary infertility prior to investigation was 12-216 (mean = 62) months. One-hundred-and-twenty-four women conceived. The following variables achieved the 5% level of significance when a stepwise analysis was performed on all cases; the concentration of spermatozoa exhibiting slow or sluggish linear or non-linear motility (chi 2(1) = 17.57, P less than 0.0001, RR = 1.67 per 50 x 10(6)), female age (chi 2(1) = 12.44, P = 0.0004, RR = 0.92 per annum), tubal status (chi 2(1) = 12.22, P = 0.0005, RR = 2.15), length of infertility before investigation (chi 2(1) = 11.22, P = 0.0008, RR = 0.87 per annum) and past paternity (chi 2(1) = 8.43, P = 0.0037, RR = 1.81). Female age was found to be positively correlated with the incidence and severity of ovulatory dysfunction, tubal occlusive disease, pelvic adhesions and endometriosis. Where the female partner was 'normal' on investigation, all conceptions were independent of treatment to either partner.(ABSTRACT TRUNCATED AT 250 WORDS)

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KW - Age Factors

KW - Aged

KW - Endometriosis/complications

KW - Fallopian Tubes/abnormalities

KW - Female

KW - Humans

KW - Infertility, Female/etiology

KW - Infertility, Male

KW - Male

KW - Middle Aged

KW - Ovulation

KW - Pelvic Neoplasms/complications

KW - Pelvis/abnormalities

KW - Sperm Motility

KW - Time Factors

KW - Tissue Adhesions

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DO - 10.1093/oxfordjournals.humrep.a136938

M3 - Article

C2 - 2794012

VL - 4

SP - 527

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JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

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