FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions

Ivor J. Mason (Lead / Corresponding author), Frances Fuller-Pace, Rosalind Smith, Clive Dickson

    Research output: Contribution to journalArticlepeer-review

    248 Citations (Scopus)

    Abstract

    We have isolated cDNA and genomic clones for the murine FGF-7 gene and examined its expression throughout development. Transcripts were transiently detected in the developing myocardium, differentially regulated between the atrium and ventricle. The gene was also expressed in the myotomes of the somites, coincident with FGF-4 and FGF-5 transcripts, and was detected transiently in cleaved muscles. Regional expression was detected in the ventricular zone of the developing forebrain at 14.5 d.p.c. Later in development, FGF-7 RNA was detected in mesenchymal tissues suggesting a role in epithelial-mesenchymal interactions and in the dermis consistent with its proposed role as a keratinocyte mitogen. Our results suggest that FGF-7 is likely to have diverse roles during development.

    Original languageEnglish
    Pages (from-to)15-30
    Number of pages16
    JournalMechanisms of Development
    Volume45
    Issue number1
    DOIs
    Publication statusPublished - Jan 1994

    Keywords

    • Epithelial-mesenchymal interaction
    • Fibroblast growth factor
    • Forebrain
    • KGF
    • Myocardium
    • Skeletal muscle

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