Fibrinolytic response to venous occlusion in diabetics with and without microangiopathy compared to normal age and sex matched controls

TY - JOUR

T1 - Fibrinolytic response to venous occlusion in diabetics with and without microangiopathy compared to normal age and sex matched controls

AU - McLaren, M.

AU - Jennings, P. E.

AU - Forbes, C. D.

AU - Belch, J. J. F.

PY - 1990

Y1 - 1990

N2 - In adults many studies have shown abnormalities of endothelial cell function. In the control subjects t-PA levels rose significantly post occlusion. This rise was significantly reduced in the diabetic subjects especially those with microvascular complications. PAI levels fell post occlusion in all normal subjects and there was a smaller but still significant fall in the diabetics without complications. In the complicated group however levels were increased or unchanged post occlusion in all but two subjects though this did not reach statistical significance.

AB - In adults many studies have shown abnormalities of endothelial cell function. In the control subjects t-PA levels rose significantly post occlusion. This rise was significantly reduced in the diabetic subjects especially those with microvascular complications. PAI levels fell post occlusion in all normal subjects and there was a smaller but still significant fall in the diabetics without complications. In the complicated group however levels were increased or unchanged post occlusion in all but two subjects though this did not reach statistical significance.

U2 - 10.1016/0268-9499(90)90374-S

DO - 10.1016/0268-9499(90)90374-S

M3 - Article

SN - 0268-9499

VL - 4

SP - 95

EP - 96

JO - Fibrinolysis

JF - Fibrinolysis

IS - Suppl. 2

ER -