Filaggrin loss-of-function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses: part II of a prospective cohort study

Maaike J. Visser, Maarten M. Verberk, Linda E. Campbell, W. H. Irwin McLean, Florentine Calkoen, Jan G. Bakker, Frank J. H. Van Dijk, Jan D. Bos, Sanja Kezic (Lead / Corresponding author)

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    Abstract

    Background/objectives: Environmental exposure and personal susceptibility both contribute to the development of hand eczema. In this study, we investigated the effect of loss-of-function mutations in the filaggrin gene (FLG), atopic dermatitis and wet work exposure on the development of hand eczema in apprentice nurses.

    Methods: Dutch apprentice nurses were genotyped for the four most common FLG mutations; atopic dermatitis and hand eczema history were assessed by questionnaire. Exposure and hand eczema during traineeships were assessed with diary cards.

    Results: The prevalence of hand eczema during traineeships was higher among subjects with a history of hand eczema reported at inclusion. Hand washing during traineeships and at home increased the risk of hand eczema. After adjustment for the effects of exposure and FLG mutations, an odds ratio of 2.5 (90% confidence interval 1.7-3.7) was found for a history of atopic dermatitis. In this study, an increased risk of hand eczema conferred by FLG mutations could not be shown, but subjects with concomitant FLG mutations and atopic dermatitis showed the highest risk of hand eczema during traineeships.

    Conclusion: A history of atopic dermatitis, a history of hand eczema and wet work exposure were the most important factors increasing the risk of hand eczema during traineeships.

    Original languageEnglish
    Pages (from-to)139-150
    Number of pages12
    JournalContact Dermatitis
    Volume70
    Issue number3
    Early online date19 Sep 2013
    DOIs
    Publication statusPublished - Mar 2014

    Keywords

    • atopic dermatitis
    • filaggrin
    • hand eczema
    • nurses
    • occupational diseases
    • susceptibility

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    Visser, M. J., Verberk, M. M., Campbell, L. E., McLean, W. H. I., Calkoen, F., Bakker, J. G., Van Dijk, F. J. H., Bos, J. D., & Kezic, S. (2014). Filaggrin loss-of-function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses: part II of a prospective cohort study. Contact Dermatitis, 70(3), 139-150. https://doi.org/10.1111/cod.12139